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Aggrecanase and cartilage proteoglycan degradation

  • Chapter
Metalloproteinases as Targets for Anti-Inflammatory Drugs

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

The loss of aggrecan from cartilage that occurs during normal turnover and joint pathology involves the proteolytic actions of matrix metalloproteinases (MMPs) and “aggrecanase”. This definitive statement is tempered, however, by not knowing precisely which members of the MMP family are involved, and not knowing the molecular identity of aggrecanase. Since its discovery in 1991, over 120 papers and conference reports have described the catalytic actions and expression of the putative aggrecanase in animal models, in vitro systems and human disease. Modulation of aggrecanase expression by cytokines and retinoate has been examined and studies exploring the relationship between aggrecanase and MMP activities in cartilage are ongoing. Many of these studies have been facilitated by the development of novel antibodies and new substrates. This chapter will review the relatively short history of aggrecanase and its role in cartilage proteoglycan degradation.

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Authors and Affiliations

  1. Department of Paediatrics, Orthopaedic Molecular Biology Research Unit, Royal Children’s Hospital, University of Melbourne, Parkville, Victoria, 3052, Australia

    Amanda J. Fosang

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  1. Amanda J. Fosang
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  1. Roche Discovery Welwyn, Roche Products Ltd., 40 Broadwater Road, Welwyn Garden City, GB-Herfordshire, AL7 3AY, UK

    Kevin M. K. Bottomley , David Bradshaw  & John S. Nixon ,  & 

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Fosang, A.J. (1999). Aggrecanase and cartilage proteoglycan degradation. In: Bottomley, K.M.K., Bradshaw, D., Nixon, J.S. (eds) Metalloproteinases as Targets for Anti-Inflammatory Drugs. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8666-6_6

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  • DOI: https://doi.org/10.1007/978-3-0348-8666-6_6

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9724-2

  • Online ISBN: 978-3-0348-8666-6

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