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Membrane type matrix metalloproteinases: regulators of focal proteolysis

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Metalloproteinases as Targets for Anti-Inflammatory Drugs

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Proteolysis of the extracellular matrix (ECM) is a key component of the inflammatory response, not only as a feature of the structural remodelling associated with the repair process, but also as a component of the cell-cell and cell-ECM interactions underlying both processes. The role of matrix metalloproteinases (MMPs) in matrix turnover has long been under scrutiny, and it has become evident that their activities are critical necessitating several levels of regulation in vivo. Most MMPs are not present at high levels in normal tissues and their expression is tightly regulated by growth factors and cytokines when remodelling does occur. The MMPs are generally secreted into the extracellular environment as inactive proenzymes, an important level of regulation of their activity then being their conversion to the active form by proteolytic removal of the propeptide. Association of MMPs with the cell surface or ECM components modulates their relationship with substrates, activators and inhibitors, acting as further levels for the regulation of their activity.

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  1. School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK

    Gillian Murphy & Vera Knäuper

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  1. Gillian Murphy
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  2. Vera Knäuper
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  1. Roche Discovery Welwyn, Roche Products Ltd., 40 Broadwater Road, Welwyn Garden City, GB-Herfordshire, AL7 3AY, UK

    Kevin M. K. Bottomley , David Bradshaw  & John S. Nixon ,  & 

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Murphy, G., Knäuper, V. (1999). Membrane type matrix metalloproteinases: regulators of focal proteolysis. In: Bottomley, K.M.K., Bradshaw, D., Nixon, J.S. (eds) Metalloproteinases as Targets for Anti-Inflammatory Drugs. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8666-6_5

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  • DOI: https://doi.org/10.1007/978-3-0348-8666-6_5

  • Publisher Name: Birkhäuser, Basel

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