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Airway epithelial cells

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Cellular Mechanisms in Airways Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

The epithelial lining of the airways forms the first line of defence against toxic and infectious agents in the inspired air. Although airway epithelial cells have traditionally been seen to play a vital role in providing an impermeable barrier and clearing the airways of noxious inhaled agents, through efficient mucociliary clearance, there is now increasing evidence to suggest that airway epithelial cells play a more important physico-chemical role. Several studies have demonstrated that epithelial cells are capable of synthesising and releasing several biologically active mediators which directly or indirectly influence the activity of inflammatory cells important in allergic airway diseases, including allergic rhinitis and asthma [1].

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Authors and Affiliations

  1. Academic Department of Respiratory Medicine, St. Bartholomew’s and The Royal London School of Medicine and Dentistry, The London Chest Hospital, London, E2 9JX, UK

    Jagdish Laxman Devalia, Jia Hua Wang & Robert James Davies

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  1. Jagdish Laxman Devalia
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  2. Jia Hua Wang
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  3. Robert James Davies
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Editors and Affiliations

  1. The Sackler Institute of Pulmonary Pharmacology, King’s College, London, SE1 9RT, UK

    Clive P. Page

  2. GKT School of Biomedical Sciences, Guy’s Campus, London, SE1 9RT, UK

    Clive P. Page

  3. Pfizer Central Research Postcode 826, Ramsgate Road Sandwich, Kent, CT13 9NJ, UK

    Katharine H. Banner

  4. The Sackler Institute of Pulmonary Pharmacology, King’s College, Bessemer Road, London, SE5 9PJ, UK

    Domenico Spina

  5. Department of Respiratory Medicine and Allergy, GKT School of Medicine, Bessemer Road, London, SE5 9PJ, UK

    Domenico Spina

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Devalia, J.L., Wang, J.H., Davies, R.J. (2000). Airway epithelial cells. In: Page, C.P., Banner, K.H., Spina, D. (eds) Cellular Mechanisms in Airways Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8476-1_9

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  • DOI: https://doi.org/10.1007/978-3-0348-8476-1_9

  • Publisher Name: Birkhäuser, Basel

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