Skip to main content
SpringerLink
Log in

Role of basophils in airways inflammation

  • Chapter
Cellular Mechanisms in Airways Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

  • 92 Accesses

Abstract

Human basophils were first identified by Paul Ehrlich (1878) thanks to the metachromatic staining properties of their cytoplasmic granules [1, 2]. In all mammalian species analysed so far, basophils and mast cells are the only cells that synthesize histamine and express plasma membrane receptors that bind with high affinity the Fce portion of IgE (FcεRI) [3]. Human basophils derive from precursors that originate in the bone marrow and in foetal liver and that circulate in peripheral blood. Under normal conditions, basophils are never found in human healthy tissues. Basophils differentiate and mature in the bone marrow and circulate in the blood with a prevalence of ≅ 0.5% of total leukocytes [4]. Under certain circumstances, basophils can be recruited into the inflamed tissue during specific IgEdependent reactions and in association with a variety of pathologic conditions [5–8]. Increasing evidence suggests that basophils and their mediators are involved in delayed-type hypersensitivity reactions in the human skin and in the lung [5,6, 8, 9].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ehrlich P (1878) Beitrage zur Theorie und Praxis der histologischen Färbung. Leipzig,Thesis

    Google Scholar 

  2. Ehrlich P (1879) Beiträge zur Kenntniss der granulirten Bindegewebszellen und der eosinophilen Leukocythen. Arch Anat Physiol 166–169

    Google Scholar 

  3. Scharenberg AM, Kinet J-P (1995) Early events in mast cell signal transduction. In: Marone G (ed): Human basophils and mast cells: biological aspects. Karger, Basel, 72–87

    Chapter  Google Scholar 

  4. Valent P (1995) Immunophenotypic characterization of human basophils and mast cells. In: Marone G (ed): Human basophils and mast cells: biological aspects. Karger, Basel, 34–48

    Chapter  Google Scholar 

  5. Liu MC, Hubbard WC, Proud D, Stealey BA, Galli SJ, Kagey-Sobotka A, Bleecker ER, Lichtenstein LM (1991) Immediate and late inflammatory responses to ragweed antigen challenge of the peripheral airways in allergic asthmatics. Cellular, mediator, and permeability changes. Am Rev Respir Dis 144: 51–58

    Article  PubMed  CAS  Google Scholar 

  6. Charlesworth EN, Kagey-Sobotka A, Schleimer RP, Norman PS, Lichtenstein LM (1991) Prednisone inhibits the appearance of inflammatory mediators and the influx of eosinophils and basophils associated with the cutaneous late-phase response to allergen. J Immunol 146: 671–676

    PubMed  CAS  Google Scholar 

  7. Koshino T, Teshima S, Fukushima N, Takaishi T, Hirai K, Miyamoto Y, Arai Y, Sano Y, Ito K, Morita Y (1993) Ientification of basophils by immunohistochemistry in the airways of post-mortem cases of fatal asthma. Clin Exp Allergy 23: 919–925

    Article  PubMed  CAS  Google Scholar 

  8. Guo C-B, Liu MC, Galli SJ, Bochner BS, Kagey-Sobotka A, Lichtenstein LM (1994) Identification of IgE-bearing cells in the late-phase response to antigen in the lung as basophils. Am J Respir Cell Mol Biol 10: 384–390

    PubMed  CAS  Google Scholar 

  9. Sparrow D, O’Connor GT, Rosner B, Weiss ST (1994) Predictors of longitudinal change in methacholine airway responsiveness among middle-aged and older men: the normative aging study. Am J Respir Crit Care Med 149: 376–381

    PubMed  CAS  Google Scholar 

  10. Valent P, Schmidt G, Besemer J, Mayer P, Zenke G, Liehl E, Hinterberger W, Lechner K, Maurer D, Bettelheim P (1989) Interleukin-3 is a differentiation factor for human basophils. Blood 73: 1763–1769

    PubMed  CAS  Google Scholar 

  11. Kirshenbaum AS, Goff JP, Kessler SW, Mican JM, Zsebo KM, Metcalfe DD (1992) Effect of IL-3 and stem cell factor on the appearance of human basophils and mast cells from CD34+ pluripotent progenitor cells. J Immunol 148: 772–777

    PubMed  CAS  Google Scholar 

  12. de Paulis A, Ciccarelli A, Cirillo R, de Crescenzo G, Columbo M, Marone G (1992) Cytokine-induced modulation of human FcεRI+ inflammatory cells. In: S Romagnani, TR Mosmann, AK Abbas (eds): New advances on cytokines. Raven Press, New York, 367–383

    Google Scholar 

  13. Brunner T, Heusser CH, Dahinden CA (1993) Human peripheral blood basophils primed by interleukin 3 (IL-3) produce IL-4 in response to immunoglobulin E receptor stimulation. J Exp Med 177: 605–611

    Article  PubMed  CAS  Google Scholar 

  14. Bochner BS, Sterbinsky SA, Briskin M, Saini SS, MacGlashan DW Jr (1996) Counter-receptors on human basophils for endothelial cell adhesion molecules. J Immunol 157: 844–850

    PubMed  CAS  Google Scholar 

  15. Saini SS, Matsumoto K, Bochner BS (1997) Phenotypic and functional characteristics of adhesion molecules on human basophils. In: BS Bochner (ed): Adhesion molecules in allergic disease. Marcel Dekker, New York, 129–138

    Google Scholar 

  16. Bochner BS, McKelvey AA, Sterbinsky SA, Hildreth JEK, Derse CP, Klunk DA, Lichtenstein LM, Schleimer RP (1990) IL-3 augments adhesiveness for endothelium and CD11b expression in human basophils but not neutrophils. J Immunol 145: 1832–1837

    PubMed  CAS  Google Scholar 

  17. Bochner BS, Sterbinsky SA (1991) Altered surface expression of CD11 and Leu 8 during human basophil degranulation. J Immunol 146: 2367–2373

    PubMed  CAS  Google Scholar 

  18. Georas SN, Liu MC, Newman W, Beall WD, Stealey BA, Bochner BS (1992) Altered adhesion molecule expression and endothelial activation accompanies the recruitment of human granulocytes to the lung following segmental antigen challenge. Am J Respir Cell Mol Biol 7: 261–269

    PubMed  CAS  Google Scholar 

  19. Columbo M, Bochner BS, Marone G (1995) Human skin mast cells express functional b1 integrins that mediate adhesion to extracellular matrix proteins. J Immunol 154: 6058–6064

    PubMed  CAS  Google Scholar 

  20. Marone G, Kagey-Sobotka A, Lichtenstein LM (1981) IgE-mediated histamine release from human basophils: differences between antigen E- and Anti-IgE-induced secretion. Int Archs Allergy Appl Immunol 65: 339–348

    Article  CAS  Google Scholar 

  21. Casolaro V, Spadaro G, Marone G (1990) Human basophil releasability. VI. Changes in basophil releasability in patients with allegic rhinitis or bronchial asthma. Am Rev Respir Dis 142: 1108–1111

    PubMed  CAS  Google Scholar 

  22. Patella V, Marinò I, Lampärter B, Arbustini E, Adt M, Marone G (1995) Human heart mast cells. Isolation, purification, ultrastructure, and immunologic characterization. J Immunol 154: 2855–2865

    PubMed  CAS  Google Scholar 

  23. Quinti I, Brozek C, Wood N, Geha RS, Leung DYM (1986) Circulating IgG autoantibodies to IgE in atopic syndromes. J Allergy Clin Immunol 77: 586–594

    Article  PubMed  CAS  Google Scholar 

  24. Marone G, Casolaro V, Quinti I, Paganelli R, Spadaro G, Stellato C (1989) Mast cell and basophil activation by human anti-IgE autoantibodies. In: JP Werner, MS Beda, C Dahinden, AR Pecoud, PC Frei, C Schneider, AL de Weck (eds): Progress in allergy and clinical immunology. Hogrefe & Huber Publishers, Toronto, 125–128

    Google Scholar 

  25. Marone G, Casolaro V, Paganelli R, Quinti I (1989) IgG anti-IgE from atopic dermatitis induces mediator release from basophils and mast cells. J Invest Dermatol 93: 246–252

    Article  PubMed  CAS  Google Scholar 

  26. Hide M, Francis DM, Grattan CEH, Hakimi J, Kochan JP, Greaves MW (1993) Autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria. N Engl J Med 328: 1599–1604

    Article  PubMed  CAS  Google Scholar 

  27. Tong LJ, Balakrishnan G, Kochan JP, Kinet J-P, Kaplan AP (1997) Assessment of autoimmunity in patients with chronic urticaria. J Allergy Clin Immunol 99: 461–465

    Article  PubMed  CAS  Google Scholar 

  28. Glovsky MM, Hugh TE, Ishizaka T, Lichtenstein LM, Erickson BW (1979) Anaphyla-toxin-induced histamine release with human leukocytes. J Clin Invest 64: 804–811

    Article  PubMed  CAS  Google Scholar 

  29. Marone G, Poto S, Petracca R, Triggiani M, De Lutio di Castelguidone E, Condorelli M (1982) Activation of human basophils by staphylococcal protein A. I. The role of cyclic AMP, arachidonic acid metabolites, microtubules and microfilaments. Clin Exp Immunol 50: 661–668

    PubMed  CAS  Google Scholar 

  30. Marone G, Columbo M, Soppelsa L, Condorelli M (1984) The mechanism of basophil histamine release induced by pepstatin A. J Immunol 133: 1542–1546

    PubMed  CAS  Google Scholar 

  31. MacGlashan DW Jr, Hubbard WC (1993) IL-3 alters free arachidonic acid generation in C5a-stimulated human basophils. J Immunol 151: 6358–6369

    PubMed  CAS  Google Scholar 

  32. Patella V, Casolaro V, Björck L, Marone G (1990) Protein L. A bacterial Ig-binding protein that activates human basophils and mast cells. J Immunol 145: 3054–3061

    PubMed  CAS  Google Scholar 

  33. Patella V, Bouvet J-P, Marone G (1993) Protein Fv produced during viral hepatitis is a novel activator of human basophils and mast cells. J Immunol 151: 5685–5698

    PubMed  CAS  Google Scholar 

  34. Patella V, Florio G, Petraroli A, Marone G (2000) HIV-1 gp120 induces IL-4 and IL-13 release from human FcεRI+ cells through interaction with the VH 3 region of IgE. J Immunol 164: 589–595

    PubMed  CAS  Google Scholar 

  35. Haak-Frendscho M, Arai N, Arai K-i, Baeza ML, Finn A, Kaplan AP (1988) Human recombinant granulocyte-macrophage colony-stimulating factor and interleukin 3 cause basophil histamine release. J Clin Invest 82: 17–20

    Article  PubMed  CAS  Google Scholar 

  36. MacDonald SM, Schleimer RP, Kagey-Sobotka A, Gillis S, Lichtenstein LM (1989) Recombinant IL-3 induces histamine release from human basophils. J Immunol 142: 3527–3532

    PubMed  CAS  Google Scholar 

  37. de Paulis A, Valentini G, Spadaro G, Lupoli S, Tirri G, Marone G (1991) Human basophil releasability. VIII. Increased basophil releasability in patients with scleroderma. Arthritis Rheum 34: 1289–1296

    Article  PubMed  Google Scholar 

  38. Bischoff SC, de Weck AL, Dahinden CA (1990) Interleukin 3 and granulocyte/ macrophage-colony-stimulating factor render human basophils responsive to low concentrations of complement component C3a. Proc Natl Acad Sci USA 87: 6813–6817

    Article  PubMed  CAS  Google Scholar 

  39. Kurimoto Y, de Weck AL, Dahinden CA (1991) The effect of interleukin 3 upon IgEdependent and IgE-independent basophil degranulation and leukotriene generation. Eur J Immunol 21: 361–368

    Article  CAS  Google Scholar 

  40. de Paulis A, Cirillo R, Ciccarelli A, Condorelli M, Marone G (1991) FK-506, a potent novel inhibitor of the release of proinflammatory mediators from human FcεRI+ cells. J Immunol 146: 2374–2381

    PubMed  Google Scholar 

  41. Brunner T, Heusser CH, Dahinden CA (1993) Human peripheral blood basophils primed by interleukin 3 (IL-3) produce IL-4 in response to immunoglobulin E receptor stimulation.J Exp Med 177: 605–611

    Article  PubMed  CAS  Google Scholar 

  42. Uguccioni M, Mackay CR, Ochensberger B, Loetscher P, Rhis S, LaRosa GJ, Rao P, Ponath PD, Baggiolini M, Dahinden CA (1997) High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines. J Clin Invest 100: 1137–1143

    Article  PubMed  CAS  Google Scholar 

  43. Weber M, Uguccioni M, Ochensberger B, Baggiolini M, Clerk-Lewis I, Dahinden CA (1995) Monocyte chemotactic protein MCP-2 activates human basophil and eosinophil leukocytes similar to MCP-3. J Immunol 154: 4166–4172

    PubMed  CAS  Google Scholar 

  44. Uguccioni M, Loetscher P, Forssmann U, Dewald B, Li H, Lima SH, Li Y, Kreider B, Garotta G, Thelen M et al (1996) Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin. J Exp Med 183: 2379–2384

    Article  PubMed  CAS  Google Scholar 

  45. Pasmans SGMA, Aalbers M, Daha MR, Knol EF, Jansen HM, Aalberse RC (1996) Histamine-releasing activity in supernatants of mononuclear cells: contribution of monocyte chemotactic protein-1 activity compared with IgE-dependent activity. J Allergy Clin Immunol 98: 962–968

    Article  PubMed  CAS  Google Scholar 

  46. MacDonald SM, Rafnar T, Langdon J, Lichtenstein LM (1995) Molecular identification of an IgE-dependent histamine-releasing factor. Science 269: 688–690

    Article  PubMed  CAS  Google Scholar 

  47. Kuna P, Reddigari SR, Rucinski D, Oppenheim JJ, Kaplan AP (1992) Monocyte chemotactic and activting factor is a potent histamine-releasing factor for human basophils. J Exp Med 175: 489–493

    Article  PubMed  CAS  Google Scholar 

  48. Alam R, Lett-Brown MA, Forsythe PA, Anderson-Walters DJ, Kenamore C, Kormos C, Grant JA (1992) Monocyte chemotactic and activating factor is a potent histamine-releasing factor for basophils. J Clin Invest 89: 723–728

    Article  PubMed  CAS  Google Scholar 

  49. Columbo M, Casolaro V, Warner JA, MacGlashan DW Jr, Kagey-Sobotka A, Lichtenstein LM (1990) The mechanism of mediator release from human basophils induced by platelet-activating factor J Immunol 145: 3855–3861

    PubMed  CAS  Google Scholar 

  50. Bürgi B, Otten UH, Ochensberger B, Rihs S, Heese K, Ehrhard PB, Ibanez CF, Dahinden CA (1996) Basophil priming by neurotrophic factors. Activation through the trk receptor. J Immunol 157: 5582–5588

    PubMed  Google Scholar 

  51. Saito H, Ebisawa M, Tachimoto H, Shichijo M, Fukagawa K, Matsumoto K, Likura Y, Awaji T, Tsujimoto G, Yanagida M et al (1996) Selective growth of human cells induced by steel factor, IL-6, and prostaglandin E2 from cord blood mononuclear cells. J Immunol 157: 343–350

    PubMed  CAS  Google Scholar 

  52. Columbo M, Horowitz EM, Botana LM, MacGlashan DW Jr, Bochner BS, Gillis S, Zsebo KM, Galli SJ, Lichtenstein LM (1992) The human recombinant c-kit receptor ligand, rhSCF, induces mediator release from human cutaneous mast cells and enhances IgE-dependent mediator release from both skin mast cells and peripheral blood basophils. J Immunol 149: 599–608

    PubMed  CAS  Google Scholar 

  53. de Paulis A, Ciccarelli A, Cirillo R, de Crescenzo G, Columbo M, Marone G (1992) Modulation of human lung mast cell function by the c-kit receptor ligand. Int Arch Allergy Immunol 99: 326–329

    Article  Google Scholar 

  54. Patella V, Casolaro V, Ciccarelli A, Pettit GR, Columbo M, Marone G (1995) The antineoplastic bryostatins affect human basophils and mast cells differently. Blood 85: 1272–1281

    PubMed  CAS  Google Scholar 

  55. Stellato C, de Paulis A, Cirillo R, Mastronardi P, Mazzarella B, Marone G (1991) Heterogeneity of human mast cells and basophils in response to muscle relaxants. Anesthesiology 74: 1078–1086

    Article  PubMed  CAS  Google Scholar 

  56. Stellato C, Casolaro V, Ciccarelli A, Mastronardi P, Mazzarella B, Marone G (1991) General anaesthetics induce only histamine release selectively from human mast cells. Br J Anaesthesia 67: 751–758

    Article  Google Scholar 

  57. Stellato C, Cirillo R, de Paulis A, Casolaro V, Patella V, Mastronardi P, Mazzarella B, Marone G (1992) Human basophil/mast cell releasability. IX. Heterogeneity of the effects of opioids on mediator release. Anesthesiology 77: 932–940

    Article  PubMed  CAS  Google Scholar 

  58. Patella V, de Crescenzo G, Marino I, Genovese A, Adt M, Gleich GJ, Marone G (1996) Eosinophil granule proteins activate human heart mast cells. J Immunol 157: 1219–1225

    PubMed  CAS  Google Scholar 

  59. de Paulis A, Marinò I, Ciccarelli A, de Crescenzo G, Concardi M, Verga L, Arbustini E, Marone G (1996) Human synovial mast cells. I. Ultrastructure in situ and in vitro immunologic characterization. Arthritis Rheum 39: 1222–1233

    Article  PubMed  Google Scholar 

  60. Metcalfe DD, Lewis RA, Silbert JE, Rosenberg RD, Wasserman SI, Austen KF (1979) Isolation and characterization of heparin from human lung. J Clin Invest 4: 1537–1543

    Article  Google Scholar 

  61. Metcalfe DD, Bland CE, Wasserman SI (1984) Biochemical and functional characterization of proteoglycans isolated from basophils of patients with chronic myelogenous leukaemia. J Immunol 132: 1943–1950

    PubMed  CAS  Google Scholar 

  62. Chieffi Baccari G, de Paulis A, Di Matteo L, Gentile M, Marone G, Minucci S (1998) In situ characterization of mast cells in the frog Rana esculenta.Cell & Tissue Res 292: 151–162

    Article  CAS  Google Scholar 

  63. Triggiani M, Casolaro V, Genovese A, Spadaro G, Marone G (1993) Heterogeneity of human FcεRI-bearing cells. Ann Allergy 71: 133–138

    PubMed  CAS  Google Scholar 

  64. Dahinden CA, Clancy RM, Gross M, Chiller JM, Hugh TE (1985) Leukotriene C4 production by murine mast cells: evidence of a role for extracellular leukotriene A4. Proc Natl Acad Sci USA 82: 6632–6636

    Article  PubMed  CAS  Google Scholar 

  65. Triggiani M, Oriente A, de Crescenzo G, Marone G (1995) Metabolism of lipid mediators in human basophils and mast cells. In: G Marone (ed): Human basophils and mast cells: biological aspects. Karger, Basel, 135–147

    Chapter  Google Scholar 

  66. Triggiani M, Oriente A, Marone G (1994) Differential roles for triglyceride and phospholipid pools of arachidonic acid in human lung macrophages. J Immunol 152: 1394–1403

    PubMed  CAS  Google Scholar 

  67. Orning L, Krivi G, Fitzpatrick FA (1991) Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes. J Biol Chem 266: 1375–1378

    PubMed  CAS  Google Scholar 

  68. Yoshimoto T, Soberman RJ, Spur B, Austen KF (1988) Properties of highly purified leukotriene C4 synthase of guinea pig lung. J Clin Invest 81: 866–871

    Article  PubMed  CAS  Google Scholar 

  69. Lewis RA, Austen KF, Soberman RJ (1990) Leukotrienes and other products of the 5- lipoxygenase pathway. N Engl J Med 323: 645–655

    Article  PubMed  CAS  Google Scholar 

  70. Marone G, Columbo M, Triggiani M, Cirillo R, Genovese A, Formisano S (1987) Inhibition of IgE-mediated release of histamine and peptide leukotriene from human basophils amd mast cells by forskolin. Biochem Pharmacol 36: 13–20

    Article  PubMed  CAS  Google Scholar 

  71. Genovese A, Patella V, de Crescenzo G, de Paulis A, Spadaro G, Marone G (1997) Loratadine and desethoxylcarbonyl-loratadine inhibit the immunological release of mediators from human FcεRI+ cells. Clin Exp Allergy 27: 559–567

    Article  PubMed  CAS  Google Scholar 

  72. Adelroth E, Morris MM, Hargreave FE, O’Byrne PM (1986) Airway responsiveness to leukotrienes C4 and D4 and to methacholine in patients with asthma and normal controls. N Engl J Med 315: 480–484

    Article  PubMed  CAS  Google Scholar 

  73. Israel E, Juniper EF, Callaghan JT, Mathur PN, Morris MM, Dowell AR, Enas GG, Hargreave FE, Drazen JM (1989) Effect of a leukotriene antagonist, LY171883, on cold air-induced bronchoconstriction in asthmatics. Am Rev Respir Dis 140: 1348–1353

    Article  PubMed  CAS  Google Scholar 

  74. Manning PJ, Watson RM, Margolskee DJ, Williams VC, Schwartz JI, O’Byrne PM (1990) Inhibition of exercise-induced bronchoconstriction by MK-571, a potent leukotriene D4-receptor antagonist. N Engl J Med 323: 1736–1739

    Article  PubMed  CAS  Google Scholar 

  75. Israel E, Dermarkarian R, Rosenberg M, Sperling R, Taylor G, Rubin P, Drazen JM (1990) The effects of a 5-lipoxygenase inhibitor on asthma induced by cold, dry air. N Engl J Med 323: 1740–1744

    Article  PubMed  CAS  Google Scholar 

  76. Knapp HR (1990) Reduced allergen-induced nasal congestion and leukotriene synthesis with an orally active 5-lipoxygenase inhibitor. N Engl J Med 323: 1745–1748

    Article  PubMed  CAS  Google Scholar 

  77. Triggiani M, De Marino V, Sofia M, Faraone S, Ambrosio G, Carrath L, Marone G (1997) Characterization of platelet-activating factor acetylhydrolase in human bronchoalveolar lavage. Am J Respir Crit Care Med 156: 94–100

    CAS  Google Scholar 

  78. Fonteh AN, Bass DA, Marshall LA, Seeds M, Samet JM, Chilton FH (1994) Evidence that secretory phospholipase A2 plays a role in arachidonic acid release and eicosanoid biosynthesis by mast cells. J Immunol 152: 5438–5446

    PubMed  CAS  Google Scholar 

  79. Fonteh AN, Samet JM, Chilton FH (1995) Regulation of arachidonic acid, eicosanoid, and phospholipase A2 levels in murine mast cells by recombinant stem cell factor. J Clin Invest 96: 1432–1439

    Article  PubMed  CAS  Google Scholar 

  80. Clark JD, Lin LL, Kriz RW, Ramesha CS, Sultzman LA, Lin AY, Milona N, Knopt JL (1991) A novel arachidonic-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and Gap. Cell 65: 1043–1051

    Article  PubMed  CAS  Google Scholar 

  81. Nakatani Y, Murakami M, Kudo I, Inoue K (1994) Dual regulation of cytosolic phospholipase A2 in mast cells after cross-linking of Fa-receptor. J Immunol 153: 796–803

    PubMed  CAS  Google Scholar 

  82. Murakami M, Matsumoto R, Urade Y, Austen KF, Arm JP (1995) c-Kit ligand mediates increased expression of cytosolic phospholipase A2, prostaglandin endoperoxide synthase-1, and hematopoietic prostaglandin D2 synthase and increased IgE-dependent prostaglandin D2 generation in immature mouse mast cells. J Biol Chem 270: 3239–3246

    Article  PubMed  CAS  Google Scholar 

  83. Murakami M, Kudo I, Suwa Y, Inoue K (1992) Release of 14-kDa group II phospholipase A2 from activated mast cells and its possible involvement in the regulation of the degranulation process. Eur J Biochem 209: 257–265

    Article  PubMed  CAS  Google Scholar 

  84. Chilton FH, Averill FJ, Hubbard WC, Fonteh AN, Triggiani M, Liu MC (1996) Antigen-induced generation of lyso-phospholipids in human airways. J Exp Med 183: 2235–2245

    Article  PubMed  CAS  Google Scholar 

  85. Hara S, Kudo I, Chang H-W, Matsuta K, Miyamoto T, Inoue K (1989) Purification and characterization of extracellular phospholipase A2 from human synovial fluid in rheumatoid arthritis. J Biochem (Tokyo) 105: 395–399

    CAS  Google Scholar 

  86. Edelson JD, Vadas P, Villar J, Mullen JBM, Pruzanski W (1991) Acute lung injury induced by phospholipase A2. Structural and functional changes. Am Rev Respir Dis 143: 1102–1109

    PubMed  CAS  Google Scholar 

  87. Murakami M, Kudo I, Inoue K (1991) Eicosanoid generation from antigen-primed mast cells by extracellular 14-kDa group II phospholipase A2. FEBS Lett 294: 247–251

    Article  PubMed  CAS  Google Scholar 

  88. Benveniste J, Henson PM, Cochrane CG (1972) Leukocyte-dependent histamine release from rabbit platelets. The role of IgE, basophils, and a platelet-activating factor. J Exp Med 136: 1356–1377

    Article  CAS  Google Scholar 

  89. Demopoulos CA, Pinckard RN, Hanahan DJ (1979) Platelet-Activating Factor. Evidence for 1–0-alkyl-2-acetyl-sn-glycery1–3-phosphorylcholine as the active component (a new class of lipid chemical mediators). J Biol Chem 254: 9355–9358

    PubMed  CAS  Google Scholar 

  90. Triggiani M, Hubbard WC, Chilton FH (1990) Synthesis of 1-acyl-2-acetyl-sn-glycero3-phosphocholine by an enriched preparation of the human lung mast cell. J Immunol 144: 4773–4780

    PubMed  CAS  Google Scholar 

  91. Triggiani M, Schleimer RP, warner JA, Chilton FH (1991) Differential synthesis of 1- acy1–2-acetyl-sn-glycero-3-phosphocholine and platelet-activating factor by human inflammatory cells. J Immunol 147: 660–666

    PubMed  CAS  Google Scholar 

  92. Arock M, Merle-Béral H, Dugas B, Ouaaz F, Le Goff L, Vouldoukis I, Mencia-Huerta J-M, Schmitt C, Leblond-Missenard V, Debre P et al (1993) IL-4 release by human leukemic and activated normal basophils. J Immunol 151: 1441–1447

    PubMed  CAS  Google Scholar 

  93. MacGlashan D Jr, White JM, Huang S-K, Ono SJ, Schroeder JT, Lichtenstein LM (1994) Secretion of IL-4 from human basophils. The relationship between IL-4 mRNA and protein in resting and stimulated basophils. J Immunol 152: 3006–3016

    PubMed  CAS  Google Scholar 

  94. Ochensberger B, Daepp G-C, Rihs S, Dahinden CA (1996) Human blood basophils produce interleukin-13 in response to IgE-receptor-dependent and -independent activation. Blood 88: 3028–3037

    PubMed  CAS  Google Scholar 

  95. Li H, Sim TC, Alam R (1996) IL-13 released by and localized in human basophils. J Immunol 156: 4833–4838

    CAS  Google Scholar 

  96. Ohkawara Y, Yamauchi K, Tanno Y, Tamura G, Ohtani H, Nagura H, Ohkuda K, Takishima T (1992) Human lung mast cells and pulmonary macrophages produce tumor necrosis factor-a in sensitized lung tissue after IgE receptor triggering. Am J Respir Cell Mol Biol 7: 385–392

    PubMed  CAS  Google Scholar 

  97. Bradding P, Roberts JA, Britten KM, Montefort S, Djukanovic R, Mueller R, Heusser C H, Howarth PH, Holgate ST (1994) Interleukin-4, -5, and -6 and tumor necrosis factor-a in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol 10: 471–480

    PubMed  CAS  Google Scholar 

  98. Bradding P, Okayama Y, Howarth PH, Church MK, Holgate ST (1995) Heterogeneity of human mast cells based on cytokine content. J Immunol 155: 297–307

    PubMed  CAS  Google Scholar 

  99. Krüger-Krasagakes S, Möller A, Kolde G, Lippert U, Weber M, Henz BM (196) Production of interleukin-6 by human mast cells and basophilic cells. J Invest Dermatol 106: 75–79

    Article  Google Scholar 

  100. Burd PR, Thompson WC, Max EE, Mills FC (1995) Activated mast cells produce interleukin 13. J Exp Med 181: 1373–1380

    Article  PubMed  CAS  Google Scholar 

  101. Marone G, Casolaro V, Patella V, Florio G, Triggiani M (1997) Molecular and cellular biology of mast cells and basophils. Int Arch Allergy Immunol 114: 207–217

    Article  PubMed  CAS  Google Scholar 

  102. Patella V, Giuliano A, Bouvet J-P, Marone G (1998) Endogenous superallergen protein Fv induces IL-4 secretion from human FcεRI+ cells through interaction with the VH3 region of IgE. J Immunol 161: 5647–5655

    PubMed  CAS  Google Scholar 

  103. Patella V, Marine I, Arbustini E, Lamparter-Schummert B, Verga L, Adt M, Marone G (1998) Stem cell factor in mast cells and increased mast cell density in idiopathic and ischemic cardiomyopathy. Circulation 97: 971–978

    Article  PubMed  CAS  Google Scholar 

  104. Li H, Sim TC, Grant JA, Alam R (1996) The production of macrophage inflammatory protein-1α by human basophils. J Immunol 157: 1207–1212

    PubMed  CAS  Google Scholar 

  105. Zon LI, Yamaguchi Y, Yee K, Albee EA, Kimura A, Bennett JC, Orkin SH, Ackerman SJ (1993) Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription. Blood 81: 3234–3243

    PubMed  CAS  Google Scholar 

  106. Rao A (1994) NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes. Immunol Today 15: 274–281

    Article  PubMed  CAS  Google Scholar 

  107. Dunnill MS (1960) The pathology of asthma with special reference to changes in the bronchial mucosa. J Clin Path 13: 27–33

    Article  PubMed  CAS  Google Scholar 

  108. Glynn AA, Michaels L (1960) Bronchial biopsy in chronic bronchitis and asthma. Thorax 15: 142–151.

    Article  CAS  Google Scholar 

  109. Laitinen LA, Heino M, Laitinen A, Kava T, Haahtela T (1985) Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Respir Dis 131: 599–606

    PubMed  CAS  Google Scholar 

  110. Chung KF (1986) Role of inflammation in the hyperreactivity of the airways in asthma. Thorax 41: 657–662

    Article  PubMed  CAS  Google Scholar 

  111. Kimura I, Tanizaki Y, Saito K, Takahashi K, Ueda N, Sato S (1975) Appearance of basophils in the sputum of patients with bronchial asthma. Clin Allergy 5: 95–98

    Article  PubMed  CAS  Google Scholar 

  112. Hastie R, Heroy JH III, Levy DA (1979) Basophil leukocytes and mast cells in human nasal secretions and scrapings studied by light microscopy. Lab Invest 40: 554–561

    PubMed  CAS  Google Scholar 

  113. Creticos PS, Peters SP, Adkinson NF Jr, Naclerio RM, Hayes EC, Norman PS, Lichtenstein LM (1984) Peptide leukotriene release after antigen challenge in patients sensitive to ragweed. N Engl J Med 310: 1626–1630

    Article  PubMed  CAS  Google Scholar 

  114. Tomioka M, Ida S, Shindoh Y, Ishihara T, Takishima T (1984) Mast cells in bronchoalveolar lumen of patients with bronchial asthma. Am Rev Respir Dis 129: 1000–1005

    PubMed  CAS  Google Scholar 

  115. Marone G, Casolaro V, Ayala F, Melillo G, Condorelli M (1990) Releasability in allergic disorders. In: G Melillo, PS Norman, G Marone (eds): Respiratory allergy. Clinical immunology, vol 2. B.C. Decker, Toronto, 67–77

    Google Scholar 

  116. Casolaro V, Spadaro G, Marone G (1993) Genetic studies of basophil releasability. In: DG Marsh, A Lockhart, ST Holgate (eds): The genetics of asthma. Blackwell Scientific Publications Ltd, Oxford, 22: 291–308

    Google Scholar 

  117. Marone G, Spadaro G, Patella V, Genovese A (1994) The clinical relevance of basophil releasability. J Allergy Clin Immunol 94: 1293–1303

    Article  PubMed  CAS  Google Scholar 

  118. Marone G, Poto S, Celestino D, Bonini S (1986) Human basophil releasability. III. Genetic control of human basophil releasability. J Immunol 137: 3588–3592

    PubMed  CAS  Google Scholar 

  119. Marone G., Spadaro G., Genovese A (1995) Pharmacological modulation of human mast cell and basophil secretion in vitro and in vivo. In: Y Kitamura, S Yamamoto, SJGalli, MW Greaves (eds): Biological and molecular aspects of mast cell and basophil differentiation and function. Raven Press, New York, 193–210

    Google Scholar 

  120. Marone G, Stellato C, Renda A, Genovese A (1993) Anti-inflammatory effects of glucocorticoids and cyclosporin A on human basophils. Eur J Clin Pharmacol 45 (Suppl 1): S17–S20

    Article  PubMed  CAS  Google Scholar 

  121. de Paulis A, Ciccarelli A, Marino I, de Crescenzo G, Marinò D, Marone G (1997) Human synovial mast cells. II. Heterogeneity of the pharmacologic effects of anti-inflammatory and immunosuppressive drugs. Arthritis Rheum 40: 469–478

    Article  PubMed  Google Scholar 

  122. Casolaro V, Spadaro G, Patella V, Marone G (1993) In vivo characterization of the anti-inflammatory effect of cyclosporin A on human basophils. J Immunol 151: 5563–5573

    PubMed  CAS  Google Scholar 

  123. Stellato C, de Paulis A, Ciccarelli A, Cirillo R, Patella V, Casolaro V, Marone G (1992) Anti-inflammatory effect of cyclosporin A on human skin mast cells. J Invest Dermatol 98: 800–804

    Article  PubMed  CAS  Google Scholar 

  124. de Paulis A, Cirillo R, Ciccarelli A, Condorelli M, Marone G (1991) FK-506, a potent novel inhibitor of the release of proinflammatory mediators from human FcεRI+ cells. J Immunol 146: 2374–2381

    PubMed  Google Scholar 

  125. de Paulis A, Cirillo R, Ciccarelli A, de Crescenzo G, Oriente A, Marone G (1991) Characterization of the anti-inflammatory effect of FK-506 on human mast cells. J Immunol 147: 4278–4285

    PubMed  Google Scholar 

  126. de Paulis A, Stellato C, Cirillo R, Ciccarelli A, Oriente A, Marone G (1992) Anti-inflam-matory effect of FK-506 on human skin mast cells. J Invest Dermatol 99: 723–728

    Article  PubMed  Google Scholar 

  127. Busse WW, Gem JE (1997) Viruses in asthma. J Allergy Clin Immunol 100: 147–150

    Article  PubMed  CAS  Google Scholar 

  128. Salvaggio J, Aukrust L (1981) Mold-induced asthma. J Allergy Clin Immunol 68: 327–346

    Article  PubMed  CAS  Google Scholar 

  129. Licorish K, Novey HS, Kozak P, Fairshter RD, Wilson AF (1985) Role of Alternaria and Penicillium spores in the pathogenesis of asthma. J Allergy Clin Immunol 76: 819–825

    Article  PubMed  CAS  Google Scholar 

  130. Marone G, Columbo M, Soppelsa L, Condorelli M (1984) The mechanism of basophil histamine release induced by pepstatin A. J Immunol 133: 1542–15

    PubMed  CAS  Google Scholar 

  131. Echtenacher B, Mannel DN, Hailer L (1996) Critical protective role of mast cells in a model of acute septic peritonitis. Nature 381: 75–77

    Article  PubMed  CAS  Google Scholar 

  132. Malaviya R, Ikeda T, Ross E, Abraham SN (1996) Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-a. Nature 381: 77–80

    Article  PubMed  CAS  Google Scholar 

  133. Bailie MB, Standiford TJ, Laichalk LL, Caffey MJ, Strieter R, Peters-Golden M (1996) Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities. J Immunol 157: 5221–5224

    PubMed  CAS  Google Scholar 

  134. de Paulis A, Ciccarelli A, de Crescenzo G, Cirillo R, Patella V, Marone G (1996) Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine. J Allergy Clin Immunol 98: 158–164

    Google Scholar 

  135. Malaviya R, Ross E, Jakschik BA, Abraham SN (1994) Mast cell degranulation induced by type 1 fimbriated Escherichia coli in mice. J Clin Invest 93: 1645–1653

    Article  PubMed  CAS  Google Scholar 

  136. Bouvet JP, Pirès R, Lunel-Fabiani F, Crescenzo-Chaigne B, Maillard P, Valla D, Opolon P, Pillot J (1990) Protein E A novel F(ab)-binding factor, present in normal liver, and largely released in the digestive tract during hepatitis. J Immunol 145: 1176–1180

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Clinical Immunology and Allergy, University of Naples Federico II, Via S. Pansini 5, Napoli, 80131, Italy

    Gianni Marone, Massimo Triggiani, Giuseppe Spadaro, Anna Maria Onorati & Arturo Genovese

Authors
  1. Gianni Marone
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Massimo Triggiani
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Giuseppe Spadaro
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Anna Maria Onorati
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Arturo Genovese
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The Sackler Institute of Pulmonary Pharmacology, King’s College, London, SE1 9RT, UK

    Clive P. Page

  2. GKT School of Biomedical Sciences, Guy’s Campus, London, SE1 9RT, UK

    Clive P. Page

  3. Pfizer Central Research Postcode 826, Ramsgate Road Sandwich, Kent, CT13 9NJ, UK

    Katharine H. Banner

  4. The Sackler Institute of Pulmonary Pharmacology, King’s College, Bessemer Road, London, SE5 9PJ, UK

    Domenico Spina

  5. Department of Respiratory Medicine and Allergy, GKT School of Medicine, Bessemer Road, London, SE5 9PJ, UK

    Domenico Spina

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer Basel AG

About this chapter

Cite this chapter

Marone, G., Triggiani, M., Spadaro, G., Onorati, A.M., Genovese, A. (2000). Role of basophils in airways inflammation. In: Page, C.P., Banner, K.H., Spina, D. (eds) Cellular Mechanisms in Airways Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8476-1_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-8476-1_2

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9583-5

  • Online ISBN: 978-3-0348-8476-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation