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T cells in the lung

  • Chapter
Cellular Mechanisms in Airways Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Because of the requirement for efficient gas exchange, the respiratory tract is particularly vulnerable to opportunistic infection. The immune system, therefore, plays a particularly vital role in protecting the respiratory mucosa from infection. The cells that orchestrate this response are immune T cells. The respiratory mucosa contains large numbers of T cells and a network of dendritic cells that present antigen to them. For many years it was thought that IgE-mediated inflammation was the only precipitating factor in asthma. Mast cells sensitised with IgE antibodies were triggered following contact with aeroallergens which caused immediate and subsequent late phase inflammatory events leading to airway narrowing and subsequently to asthma. However, studies by Kay and colleagues have shown that T cells are also directly important in asthma [1–4] as they are in the allergen-induced late phase response in the skin [5]. The airways of asthmatic patients are rich in T cells. In experimental animals, adoptive transfer of antigen-specific Th2 T cells and subsequent aerosol challenge are sufficient to induce inflammation and increase bronchial hyperresponsiveness [6, 7]. The cytokines produced by immune T cells and their contribution to allergic inflammation and asthma is the subject of this chapter.

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Authors and Affiliations

  1. Departments of Immunology, Guys, King’s and St Thomas’s School of Medicine and Dentistry,Rayne Institute, 123 Coldharbour Lane, London, SE5 9NU, UK

    David M. Kemeny

  2. Departments of Respiratory Medicine, Guys, King’s and St Thomas’s School of Medicine and Dentistry, Rayne Institute, 123 Coldharbour Lane, London, SE5 9NU, UK

    Brian J. O’Connor

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  1. David M. Kemeny
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Editors and Affiliations

  1. The Sackler Institute of Pulmonary Pharmacology, King’s College, London, SE1 9RT, UK

    Clive P. Page

  2. GKT School of Biomedical Sciences, Guy’s Campus, London, SE1 9RT, UK

    Clive P. Page

  3. Pfizer Central Research Postcode 826, Ramsgate Road Sandwich, Kent, CT13 9NJ, UK

    Katharine H. Banner

  4. The Sackler Institute of Pulmonary Pharmacology, King’s College, Bessemer Road, London, SE5 9PJ, UK

    Domenico Spina

  5. Department of Respiratory Medicine and Allergy, GKT School of Medicine, Bessemer Road, London, SE5 9PJ, UK

    Domenico Spina

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Kemeny, D.M., O’Connor, B.J. (2000). T cells in the lung. In: Page, C.P., Banner, K.H., Spina, D. (eds) Cellular Mechanisms in Airways Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8476-1_12

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  • DOI: https://doi.org/10.1007/978-3-0348-8476-1_12

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9583-5

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