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Bronchodilator Actions of Nitric Oxide and Related Compounds

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Nitric Oxide in Pulmonary Processes

Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

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Abstract

Among its many roles in mammalian cells and organisms, nitric oxide (NO) has a multitude of physiological and pathophysiological roles in the lungs and airways. In the airways, NO and NO-related compounds modulate airway tone and microvascular leak from the airway circulation, mediate enhanced ciliary motility in response to various agents, and likely contribute to epithelial injury and denudation the setting of airway inflammation. NO is synthesized by a family of NO synthases (NOSs) which are found in a variety of cell types in the lungs and airways, including bronchial epithelial cells, endothelial cells and intrinsic airway postganglionic neurons [1, 4, 7, 8, 14, 22, 24, 27, 32, 45–47, 50].

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Author information

Authors and Affiliations

  1. Pulmonary Division, Departments of Medicine and Pharmacology/Toxicology, London Health Sciences Center, University of Western Ontario, London, Ontario, Canada, NGA 4G5

    Sanjay Mehta

  2. Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA

    Jeffrey M. Drazen

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  1. Sanjay Mehta
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  2. Jeffrey M. Drazen
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Editors and Affiliations

  1. Pharmacology Department, Rhône-Poulenc Rorer Research & Development, Rainham Road South, Dagenham, Essex, RM 10 7XS, UK

    Maria G. Belvisi

  2. Unit of Critical Care Medicine Imperial College Medical School, Royal Brompton Hospital, Sidney Street, London, SW3 6NP, UK

    Jane A. Mitchell

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© 2000 Springer Basel AG

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Mehta, S., Drazen, J.M. (2000). Bronchodilator Actions of Nitric Oxide and Related Compounds. In: Belvisi, M.G., Mitchell, J.A. (eds) Nitric Oxide in Pulmonary Processes. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8474-7_7

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  • DOI: https://doi.org/10.1007/978-3-0348-8474-7_7

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9582-8

  • Online ISBN: 978-3-0348-8474-7

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