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Nitric Oxide Synthesis and Actions

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Nitric Oxide in Pulmonary Processes

Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

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Abstract

Nitric oxide (NO) is the ubiquitous activator of soluble guanylyl cyclase resulting in smooth muscle relaxation. In addition, NO can activate/inhibit a number of other proteins that influence cellular responses. Within a physiological setting, NO release by endothelial cells or nerves contributes to homeostatic processes in every organ system in the body. NO is also released as a primary defence mechanism by immune cells. However, when NO production becomes excessive, its release can contribute to the processes of inflammation and/or cardiovascular dysfunction.

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Authors and Affiliations

  1. Department of Physiology, University of Connecticut Health Center, Farmington, CT, 06030, USA

    David Bishop-Bailey

  2. Unit of Critical Care Medicine, Imperial College Medical School at the Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK

    Jane A. Mitchell

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  1. David Bishop-Bailey
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Editors and Affiliations

  1. Pharmacology Department, Rhône-Poulenc Rorer Research & Development, Rainham Road South, Dagenham, Essex, RM 10 7XS, UK

    Maria G. Belvisi

  2. Unit of Critical Care Medicine Imperial College Medical School, Royal Brompton Hospital, Sidney Street, London, SW3 6NP, UK

    Jane A. Mitchell

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Bishop-Bailey, D., Mitchell, J.A. (2000). Nitric Oxide Synthesis and Actions. In: Belvisi, M.G., Mitchell, J.A. (eds) Nitric Oxide in Pulmonary Processes. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8474-7_1

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  • DOI: https://doi.org/10.1007/978-3-0348-8474-7_1

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