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Inflammatory Processes: pp 99–107Cite as

Birkhäuser

The role of MCP-1 in disease

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Monocyte chemoattractant protein-1 (MCP-1), also known as monocyte chemotactic and activating factor (MCAF), is a CC chemokine that exerts its effects specifically on monocytes, memory T lymphocytes, NK cells, and basophils. Originally cloned as the murine JE gene on the basis of its growth factor-inducible expression [1, 2], the protein was later purified as a monocyte-specific chemoattractant [3–5]. While most chemokines bind to multiple receptors, suggesting that the chemokine system may be plagued by biological redundancy, the sole receptor for MCP-1 identified to date is CCR2 [6]. Like other chemokine receptors, CCR2 is a seven trans-membrane spanning receptor coupled predominantly to Gia, although there is evidence for coupling to other G protein subtypes as well [7].

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Author information

Authors and Affiliations

  1. Department of Adult Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA, 02115, USA

    Long Gu, Susan C. Tseng & Barrett J. Rollins

Authors
  1. Long Gu
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  2. Susan C. Tseng
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  3. Barrett J. Rollins
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Editor information

Editors and Affiliations

  1. NitroMed Inc., 12 Oak Park Drive, Bedford, MA, 01730, USA

    L. Gordon Letts

  2. Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL, 60064, USA

    Douglas W. Morgan

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© 2000 Springer Basel AG

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Gu, L., Tseng, S.C., Rollins, B.J. (2000). The role of MCP-1 in disease. In: Letts, L.G., Morgan, D.W. (eds) Inflammatory Processes:. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8468-6_10

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  • DOI: https://doi.org/10.1007/978-3-0348-8468-6_10

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9580-4

  • Online ISBN: 978-3-0348-8468-6

  • eBook Packages: Springer Book Archive

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