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The role of T cells in the pathogenesis of atopic dermatitis

  • Chapter
Immunology and Drug Therapy of Allergic Skin Diseases

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

T cells play a central role in the activation and regulation of immune responses. The T cell recognizes antigen, via the interaction between a MHC-peptide complex on the antigen presenting cells (APC) and the T cell receptor (TCR) on the T cells, leading to the induction of cytokine production by the T cell. The repertoire of secreted cytokines has an evident influence on the resulting response, directing towards either a cell-mediated T helper 1 (Th1) response or towards a humoral Th2 response [1, 2]. This will have a pronounced effect on the development of different forms of diseases. Atopic dermatitis (AD) is one of the diseases that may result from an unbalanced response of T cells upon allergen-recognition.

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  1. Department of Dermatology/Allergology, University Medical Center Utrecht, P.O. Box 85.500, Utrecht, GA, 3508, Netherlands

    Els Van Hoffen & Frank C. Van Reijsen

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  1. Els Van Hoffen
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  1. Department of Dermatology, University Hospital Utrecht, Heidelberglaan 100, Utrecht, CX, NL-3584, Netherlands

    C. A. F. M. Bruijnzeel-Koomen  & E. Knol  & 

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Van Hoffen, E., Van Reijsen, F.C. (2000). The role of T cells in the pathogenesis of atopic dermatitis. In: Bruijnzeel-Koomen, C.A.F.M., Knol, E. (eds) Immunology and Drug Therapy of Allergic Skin Diseases. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8464-8_3

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  • DOI: https://doi.org/10.1007/978-3-0348-8464-8_3

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9579-8

  • Online ISBN: 978-3-0348-8464-8

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