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New Cytokines as Potential Drugs pp 101–119Cite as

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Keratinocyte growth factor-2

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Growth factors are a group of hormone-like polypeptides playing a central role in the complex processes of tissue repair. In the case of repair of cutaneous wounds specific growth factors stimulate keratinocyte migration into the wounds and are present in wound fluid [1]. Growth factors such as platelet-derived growth factor (PDGF), fibroblast growth factor-2 (FGF-2) and transforming growth factor-β (TGF-β3) are currently in clinical trials of chronic skin wounds while epidermal growth factor (EGF) is being used in clinical trials of ocular wound healing. EGF and PDGFs have demostrated acceleration of epidermal regeneration in cutaneous wounds in man [2-5].

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Authors and Affiliations

  1. Human Genome Sciences, Inc., 9410 Key West Avenue, Rockville, MD, 20850, USA

    Pablo A. Jimenez, Dale Greenwalt, Donna L. Mendrick, Mark A. Rampy, Jeffrey Su, Kam H. Leung & Kevin M. Connolly

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  1. Pablo A. Jimenez
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Editors and Affiliations

  1. Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ, 07033, USA

    Satwant K. Narula

  2. DNAX Research Institute, 901 California Avenue, Palo Alto, CA, 94304, USA

    Robert Coffman

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Jimenez, P.A. et al. (2000). Keratinocyte growth factor-2. In: Narula, S.K., Coffman, R. (eds) New Cytokines as Potential Drugs. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8456-3_7

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  • DOI: https://doi.org/10.1007/978-3-0348-8456-3_7

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