Abstract
Since the first sequence of Interleukin (IL)-17 was published in 1993 [1], very little data have accumulated concerning its potential role in diseases. In vitro and in vivo studies suggest a proinflammatory function for this Interleukin but no data firmly establishes the status of IL-17 as the molecule to target in order to control the inflammatory response. The scope of this chapter is therefore a panoramic view of the pathologies where IL-17 appears to be involved.
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References
Rouvier E, Luciani M-F, Mattéi M-G, Denizot F, Golstein P (1993) CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus Saimiri gene. J Immunol 150: 5445–5456
Kennedy J, Rossi DL, Zurawski SM, Vega F, Kastelein RA, Wagner JL, Hannum CH, Zlotnik A (1996) Mouse IL-17: a cytokine preferentially expressed by αβ3TCR+CD4-CD8-T cells. J Interferon Res and Cytokine Res 16: 611–617
Fossiez F, Djossou O, Chomarat P, Florès-Romo L, Ait-Yahia S, Maat C, Pin JJ, Garrone P, Garcia E, Saeland S et al (1996) T-cell IL-17 induces stromal cells to produce proin-flammatory and hematopoietic cytokines. J Exp Med 183: 2593–2603
Yao Z, Painter SL, Fanslow WC, Ulrich D, Macduff BM, Spriggs MK, Armitage RJ (1995) Human IL-17: a novel cytokine derived from T cells. J Immunol 155: 5483–5486
Yao Z, Timour M, Painter S, Fanslow W, Spriggs M (1996) Complete nucleotide sequence of the mouse CTLA8 gene. Gene 168: 223–225
Albrecht JC, Nicholas J, Biller D, Cameron KR, Biesinger B, Newman C, Wittmann S, Craxton MA, Coleman H, Fleckenstein B (1992) Primary structure of the herpes virus saimiri genome. J Virol 66: 5047–5058
Yao Z, Fanslow WC, Seldin MF, Rousseau AM, Painter SL, Comeau MR, Cohen JI, Spriggs MK (1995) Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity 3: 811–821
Knappe A, Hiller C, Niphuis H, Fossiez F, Thurau M, Wittmann S, Kuhn EM, Lebecque S, Banchereau J, Rosenwirth B et al (1998) The Interleukin-17 gene of herpesvirus Saimiri. J Virol 72: 5797–5801
Teunissen MBM, Koomen CW, de Waal Malefyt R, Wierenga EA, Bos JD (1998) Interleukin-17 and interferon-y synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. Invest Dermatol 111: 645–649
van Kooten C, Boonstra JG, Paape ME, Fossiez F, Banchereau J, Lebecque S, Bruijn JA, de Fijter JW, van Es LA, Daha MR (1998) Interleukin-17 activates human renal epithelial cells in vitro and is expressed during renal allograft rejection. J Am Soc Nephrol 9: 1526–1534
Jovanovic DV, Di Battista JA, Martel-Pelletier J, Jolicoeur FC, He Y, Zhang M, Mineau F, Pelletier JP (1998) IL-17 stimulates the production and expression of proinflammatory cytokines, IL-lβ and TNFa, by human macrophages. J Immunol 160: 3513–3521
Attur MG, Patel RN, Abramson SB, Amin AR (1997) Interleukin-17 up-regulation of nitric oxide production in human osteoarthritis cartilage. Arth & Rheum 40: 1050–1053
Shalom-Barak T, Quach J, Lotz M (1998) Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinas-es and NF-kappaB. J Biol Chem 273: 27467–27473
Cai XY, Gommoll CP Jr, Justice L, Narula SK, Fine JS (1998) Regulation of granulocyte colony-stimulating factor gene expression by interleukin-1.7 Immunol Letters 62: 51–58
Yao Z, Spriggs MK, Derry JMJ, Strockbine L, Park LS, VandenBos T, Zappone JD, Painter SL, Armitage RJ (1997) Molecular characterization of the human Interleukin (IL)-17 receptor. Cytokine 9: 794–800
Chabaud M, Fossiez F, Taupin JL, Miossec P (1998) Enhancing effect of IL-17 on IL-1 induced IL-6 and LIF production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines. J Immunol 161: 409–414
Strehlau J, Pavlakis M, Lipman M, Shapiro M, Vasconcellos L, Harmon W, Strom TB (1997) Quantitative detection of immune activation transcripts as a diagnostic tool in kidney transplantation. Proc Natl Acad Sci USA 94: 695–700
Armitage RJ, Fanslow WC, Strockbine L, Sato TA, Clifford KN, Macduff BM, Anderson DM, Gimpel SD, Davis-Smith T, Maliszewski CR et al (1992) Molecular and biological characterization of a murine ligand for CD40. Nature 357: 80–82
van Kooten C, Gerritsma JSJ, Paape ME, van Es LA, Banchereau J, Daha MR (1997) Possible role for CD40-CD40L in the regulation of interstitial infiltration in the kidney. Kidney Int 51: 711–721
Antonysamy MA, Fu F, Li W, Qian S, Troutt AB, Thomson AW, Fanslow WC (1997) Prolongation of cardiac allograft survival by recombinant IL-17R: Fc. The Fifth Basic Sciences Symposium of the Transplantation Society
Antonysamy MA, Fu F, Li W, Qian S, Troutt AB, Fanslow WC, Thomson AW (1998) Evidence that IL-17 promotes DC maturation and alloimmune reactivity. Keystone Symposia on Molecular and Cellular Biology Cellular and Molecular Biology of Dendritic Cells 44
Spriggs M (1997) Interleukin-17 and its receptor. J Clin Immunol 17: 366–369
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Fossiez, F., Nicolas, JF., Lebecque, S. (2000). Interleukin 17. In: Narula, S.K., Coffman, R. (eds) New Cytokines as Potential Drugs. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8456-3_4
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DOI: https://doi.org/10.1007/978-3-0348-8456-3_4
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