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Retinoid treatment of photoaged skin

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Vitamin A and Retinoids: An Update of Biological Aspects and Clinical Applications

Part of the book series: MCBU Molecular and Cell Biology Updates ((MCBU))

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Abstract

Photoaging comprises the adverse effects of chronic ultraviolet radiation (UVR) on the skin, superimposed on the intrinsic aging process [1]. The magnitude of the problem of photoaging is large and expanding [2] as a result of factors such as increasing ultraviolet exposure from ozone layer depletion, increasing popularity of tanning salons, and “sun-worshipping” behavior of the public, combined with demographic shifts that have tripled the proportion of older persons in society during the past century and are projected again to double in the next century [3]. Ongoing public awareness of the consequences of chronic sun exposure has not yet diminished the population’s desire to tan or motivation to use adequate sun protection measures. Consequently, photoaging is a common reason for consulting dermatologists and other physicians, and the public interest in products intended to reverse its effects is enormous. This chapter reviews evidence gathered from human and animal studies regarding the ability of topical retinoid application to reverse many aspects of the photoaging process.

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Authors and Affiliations

  1. Department of Dermatology, Boston University School of Medicine, Boston, MA, 02118, USA

    A. A. Bajoghli & B. A. Gilchrest

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  1. A. A. Bajoghli
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  2. B. A. Gilchrest
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  1. Cattedra di Chimica Biologica, Istituto di Farmacologia e Farmacognosia, Università di Palermo, Via Forlanini 1, Palermo, I-90134, Italy

    Maria A. Livrea

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Bajoghli, A.A., Gilchrest, B.A. (2000). Retinoid treatment of photoaged skin. In: Livrea, M.A. (eds) Vitamin A and Retinoids: An Update of Biological Aspects and Clinical Applications. MCBU Molecular and Cell Biology Updates. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8454-9_21

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  • DOI: https://doi.org/10.1007/978-3-0348-8454-9_21

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9574-3

  • Online ISBN: 978-3-0348-8454-9

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