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Synthetic retinoids and their usefulness in biology and medicine

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Vitamin A and Retinoids: An Update of Biological Aspects and Clinical Applications

Part of the book series: MCBU Molecular and Cell Biology Updates ((MCBU))

Abstract

The natural retinoids—all-trans-retinoic acid (trans-RA) and its 9-cis isomer (9-cis-RA)—and their synthetic analogs have important functions in regulating cell proliferation, differentiation, and morphogenesis. For these reasons, retinoids are successfully used as therapeutic agents to treat several proliferative diseases, such as acne, psoriasis, skin cancer, and acute promyleoblastic leukemia, and to prevent the recurrence of head-and-neck and certain skin cancers [1-3]. Because of their ability to modulate cell differentiation and proliferation, retinoids at therapeutically effective doses may have such toxic side effects on normal cells that their use is limited [4]. A continuing goal of numerous drug development programs has been to identify therapeutically effective retinoids that have reduced systemic side effects [5] Such an approach is possible because retinoid activities are regulated through their receptor proteins.

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Authors and Affiliations

  1. Molecular Medicine Research Institute, 325 East Middlefield Road, Mountain View, CA, 94043, USA

    M. I. Dawson

  2. The Burnham Institute, 10901 N. Torrey Pines Road, La Jolla, CA, 92037, USA

    X. Zhang

  3. SRI International, 333 Ravenswood Avenue, Menlo Park, CA, 94025, USA

    P. D. Hobbs & L. Jong

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  1. M. I. Dawson
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  2. X. Zhang
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  3. P. D. Hobbs
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  4. L. Jong
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  1. Cattedra di Chimica Biologica, Istituto di Farmacologia e Farmacognosia, Università di Palermo, Via Forlanini 1, Palermo, I-90134, Italy

    Maria A. Livrea

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Dawson, M.I., Zhang, X., Hobbs, P.D., Jong, L. (2000). Synthetic retinoids and their usefulness in biology and medicine. In: Livrea, M.A. (eds) Vitamin A and Retinoids: An Update of Biological Aspects and Clinical Applications. MCBU Molecular and Cell Biology Updates. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8454-9_14

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