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TGFß and IL-10: inhibitory cytokines regulating immunity and the response to infection

  • Chapter
Novel Cytokine Inhibitors

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

A complex interplay between cytokines provides plasticity to our systems of host defense and immune surveillance, but also presents a tremendous challenge to our understanding of the host immune response. These cytokines are typically pleiotropic. They may amplify their own expression, influence the production of other cytokines and effector molecules, and exert an end-effect that is often defined by the array of other signals acting in their presence. Determining those participants which negatively regulate these effector responses may enable us to manipulate the exaggerated response, whether to pathogens or to self, and to enhance an ineffective response by interfering with their activity.

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Authors and Affiliations

  1. Institute for Clinical Microbiology, Immunology, and Hygiene, University of Erlangen-Nuremberg, Wasserturmstrasse 3, D-91054, Erlangen, Germany

    Christian Bogdan

  2. Department of Surgery, University of Pittsburgh, 200 Lothrop St., Room E1558, Pittsburgh, PA 15213, USA

    Yoram Vodovotz

  3. Lab of Cell Regulation and Carcinogenesis, Building 41, Room C629, National Cancer Institute, National Institutes of Health, Bethesda, 20892-5055, MD, USA

    John Letterio

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  1. Celltech Chiroscience, 216 Bath Road, Slough Berkshire, SL1 4EN, UK

    Gerry A. Higgs

  2. Cellular Microbiology Research Group Eastman Dental Institute, University College London, 256 Gray’s Inn Road, London, WC1X 8LD, UK

    Brian Henderson

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Bogdan, C., Vodovotz, Y., Letterio, J. (2000). TGFß and IL-10: inhibitory cytokines regulating immunity and the response to infection. In: Higgs, G.A., Henderson, B. (eds) Novel Cytokine Inhibitors. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8450-1_11

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