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Simulation models for schizophrenia

  • Chapter
Atypical Antipsychotics

Part of the book series: Milestones in Drug Therapy MDT ((MDT))

Abstract

As discussed in Ellenbroek and Cools, Animal models, this volume, the development of simulation models for schizophrenia has gained momentum in the last decade through the recognition that not only symptoms, but also psychophysiological and psychological disturbances of the disease can be used. This has led to the development of models like prepulse inhibition (PPI), P50 gating and latent inhibition. However, the development of models simulating schizophrenic symptomatology has also improved considerably. Apart from the classical models, such as apomorphine induced stereotypy, models studying social withdrawal and models analysing aspects of anhedonia have been developed. Unfortunately, only few of these models have so far been used to evaluate the effects of (atypical) antipsychotic drugs. This chapter will therefore predominantly focus on the various models that have been developed and only describe the effects of (atypical) antipsychotics when rigorous screening has been performed.

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  1. Department of Psychoneuropharmacology, University of Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands

    Bart A. Ellenbroek & Alexander R. Cools

  2. Department of Psychopharmacology, Pharmacological Research, H. Lundbeck A/S,Ottiliavej 9, Copenhagen-Valby, DK 2500, Denmark

    Frank Sams-Dodd

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Ellenbroek, B.A., Sams-Dodd, F., Cools, A.R. (2000). Simulation models for schizophrenia. In: Ellenbroek, B.A., Cools, A.R. (eds) Atypical Antipsychotics. Milestones in Drug Therapy MDT. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8448-8_7

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  • DOI: https://doi.org/10.1007/978-3-0348-8448-8_7

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