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Carbonic anhydrase research: a clinical perspective, past and future

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The Carbonic Anhydrases

Part of the book series: EXS 90 ((EXS,volume 90))

Abstract

In these recollections I apologize for being personal in my choice of topics, biased and selective in emphasising my own work and that of colleagues at the University of Uppsala. My exposure to the research on carbonic anhydrase (CA) at this university greatly influenced my decision to stay within the CA field. Over the years I have now and then been inclined to leave research and go into clinical medicine, which I finally did. In a way, this is therefore the story of why I stayed as long as I did.

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References

  • Berfenstam R (1952) Studies on carbonic anhydrase activity in children. Acta Pediat 41: 32–52

    Article  CAS  Google Scholar 

  • Berliner RW (1957) Some aspects of ion exchange in electrolyte transport by the renal tubules. In: DR Murphy (ed): Metabolic aspects of transport across cell membranes. University of Wisconsin Press, Madison, 203–220

    Google Scholar 

  • Beyer KH, Baer JE (1961) Physiological basis for the action of newer diuretic agents. Pharmacol Rev 13: 517–562

    PubMed  CAS  Google Scholar 

  • Carter ND, Wistrand PJ, Isenberg H, Askmark H, Jeffery S, Hopkinson D, Edwards Y (1988) Induction of carbonic anhydrase III mRNA and protein by denervation of rat muscle. Biochem J 256: 147–152

    PubMed  CAS  Google Scholar 

  • Chen JC, Chessler M (1992) pH transients evoked by excitatory synaptic transmission are increased by inhibition of extracellular carbonic anhydrase. Proc Natl Acad Sci USA 89: 7786–7790

    Article  PubMed  CAS  Google Scholar 

  • Comroe JH Jr, Dripps RD (1976) Scientific basis for the support of medical science. Science 192: 105–111

    Article  PubMed  Google Scholar 

  • Cox SN, Hay E, Bird AC (1988) Treatment of chronic macular edema with acetazolamide. Arch Ophthalmol 106: 1190–1195

    Article  PubMed  CAS  Google Scholar 

  • Davies RE, Roughton FJW (1948) Hydrochloric acid production by isolated gastric mucosa. Biochem J 42: 609

    CAS  Google Scholar 

  • Diaz E, Sandblom JP, Wistrand PJ (1982) Selectivity properties of channels induced by reconstituted membrane-bound carbonic anhydrase. Acta Physiol Scand 116: 461–463

    Article  PubMed  CAS  Google Scholar 

  • Dodgson SJ (1991) Liver mitochondrial carbonic anhydrase (CA V), glucogenesis, and urea-genesis in the hepatocyte. In: SJ Dodgson, RE Tashian, G Gros, ND Carter (eds): The carbonic anhydrases. Cellular physiology and molecular genetics. Plenum Press, New York, 297–306

    Google Scholar 

  • Gros G (1991) The role of carbonic anhydrase within the tissues, with special reference to mammalian striated muscle. Soc Exp Biol Semin Ser 41: 35–54

    CAS  Google Scholar 

  • Hansson HPJ (1967) Histochemial demonstration of carbonic anhydrase activity. Histochemie 11: 112–128

    Article  PubMed  CAS  Google Scholar 

  • Heiman SI, Koeppen BM, Beyenbach LW, Baxendale LM (1985) Patch clamp studies of apical membranes of renal cortical collecting ducts. PflĂĽgers Arch 405 (Suppl 1): S71–S76

    Article  Google Scholar 

  • Karlmark B, Agerup B, Wistrand PJ (1979) Renal proximal tubular acidification. Role of brush-border and cytoplasmic carbonic anhydrase. Acta Physiol Scand 106: 145–150

    Article  PubMed  CAS  Google Scholar 

  • Kendall AG, Tashian RE (1977) Erythrocyte carbonic anhydrase I: inherited deficiency in humans. Science 197: 471–472

    Article  PubMed  CAS  Google Scholar 

  • Kofor G, Toon MR, Janoshazi A, Solomon AK (1993) Interaction between red cell membrane Band 3 and cytosolic carbonic anhydrase. J Membrane Biol 134: 169–179

    Google Scholar 

  • Kinsey VE (1950) A unified concept of aqueous dynamics and the maintenance of intraocular pressure. An elaboration of the secretion-diffusion theory. Arch Ophthalmol 44: 215–231

    Article  CAS  Google Scholar 

  • Krebs HA (1948) Inhibition of carbonic anhydrase by sulfonamides. Biochem J 43: 525–528

    PubMed  CAS  Google Scholar 

  • Krupin T, Sly WS, Whyte MP, Dodgson SJ (1985) Failure of acetazolamide to decrease intraocular pressure in patients with carbonic anhydrase II deficiency. Am J Ophthalmol 99: 369–399

    Google Scholar 

  • Liljas A, Kaman KK, Bergsten PC, Waara I, Fridborg K, Strandberg B, Carlbom U, Jarup L, Lovgren S, Petef M (1972) Crystal structure of human carbonic anhydrase C. Nature,New Biol 235: 1885–1893

    Google Scholar 

  • Lindskog S, Wistrand PJ (1989) Inhibitors of carbonic anhydrase. In: M Sanders, HJ Smith (eds): Design of Enzyme Inhibitors, Oxford University Press, Oxford, 628–723

    Google Scholar 

  • Lönnerholm G (1980) Carbonic anhydrase in rat liver and rabbit skeletal muscle; further evidence for the specificity of the histochemical cobalt, phosphate method of Hansson. J Histochem Cytochem 28: 427–433

    Article  PubMed  Google Scholar 

  • Lönnerholm G, Wistrand PJ (1984) Carbonic anhydrase in the human kidney: a histochemical and immunocytochemical study. Kidney Int 25: 886–898

    Article  PubMed  Google Scholar 

  • Lucci MS, Tinker JP, Weiner M, DuBose TD Jr (1983) Function of proximal tubule carbonic anhydrase defined by selective inhibition. Am J Physiol 245: F443–F449

    PubMed  CAS  Google Scholar 

  • Lutwak-Mann C (1955) Carbonic anhydrase in the female reproductive tract. Occurrence, distribution and hormonal dependence. J Endocrinol 13: 26–38

    Article  PubMed  CAS  Google Scholar 

  • Maren TH (1979) An historical account of CO2 chemistry and the development of carbonic anhydrase inhibitors. The Pharmacologist 20: 303–321

    Google Scholar 

  • Maren TH, Conroy CW, Wynns GC, Godman GR (1997) Renal and cerebrospinal fluid. Pharmacology of a high molecular weight carbonic anhydrase inhibitor. J Pharmacol Exp Ther 280: 98–104

    PubMed  CAS  Google Scholar 

  • Matsui H, Murakami M, Wynns GC, Conroy CW, Mead A, Maren TH, Sears ML (1996) Membrane carbonic anhydrase and ciliary epithelium, Carbonic anhydrase activity is present in the basolateral membranes of the non-pigmented ciliary epithelium of rabbit eyes. Exp Eye Res 62: 409–417

    Article  PubMed  CAS  Google Scholar 

  • Murakami H, Sly WS (1987) Purification and characterization of human salivary carbonic anhydrase. J Biol Chem 262: 1382–1388

    PubMed  CAS  Google Scholar 

  • Nyman PO (1961) Purification of and properties of carbonic anhydrase from human erythrocytes. Biochim Biophys Acta 52: 1–12

    Article  PubMed  CAS  Google Scholar 

  • Ă–jteg G, Wistrand PJ (1994) Renal handling and plasma elimination kinetics of carbonic anhydrase isoenzymes I, II and III in the rat. Acta Physiol Scand 15: 531–539

    Article  Google Scholar 

  • Osterman PO, Askmark H, Wistrand PJ (1985) Serum carbonic anhydrase III in neuromuscular disorders and in healthy persons after a long-distance run. J Neurol Sci 70: 347–357

    Article  PubMed  CAS  Google Scholar 

  • Pitts RF, Alexander RS (1945) The nature of the renal tubular mechanism for acidifying the urine. Am J Physiol 144: 239–254

    CAS  Google Scholar 

  • Rector FC Jr, Carter NW, Seldin EW (1965) The mechanism of bicarbonate reabsorption in the proximal and distal tubules of the kidney. J Clin Invest 44: 278–290

    Article  PubMed  CAS  Google Scholar 

  • RidderstrĂĄle Y (1976) Intracellular localization of carbonic anhydrase in the frog nephron. Acta Physiol Scand 98: 465–469

    Article  PubMed  Google Scholar 

  • RidderstrĂĄle Y, Wistrand PJ (1997) Carbonic anhydrase isoforms in the mammalian nervous system. In: K Kaila, BR Ransom (eds): pH and Brain Function. John Wiley & Sons, New York. 21–43

    Google Scholar 

  • Roush ED, Fierke CA (1994) Purification and characterization of a carbonic anhydrase II inhibitor from porcine plasma. Biochemistry 31: 12536–12542

    Article  Google Scholar 

  • Schwartz GJ, Brown D, Mankus R, Alexander EA, Schwartz JH (1994) Low ph enhances expression of carbonic anhydrase II by cultured rat inner medullary collecting duct cells. Am J Physiol 266: C508–C514

    PubMed  CAS  Google Scholar 

  • Sly WS, Hu PY (1995) Human carbonic anhydrase and carbonic anhydrase deficiences. Annu Rev Biochem 64: 375–401

    Article  PubMed  CAS  Google Scholar 

  • Sugrue MF, Funk HA, Lazarides E, Mallorga P, O’Neill-Davis LA, Ritter PJ (1994) Evidence for a role of membrane bound carbonic anhydrase in introcular pressure regulation in rabbits. Invest Ophthalmol Pis Sci 35: (Suppl) Arvo abstract no. 672. p. 1400

    Google Scholar 

  • Sundberg L, Porath J (1974) Preparation of adsorbent for biospecific affinity chromatography. Attachment of group-containing ligands to insoluble polymers by means of bifunctional oxiranes. J Chromatography 90: 87–98

    Article  CAS  Google Scholar 

  • Supuran CT (1993) Carbonic anhydrase inhibitors-syntheses, properties and physiological significance. Rouman Chem Quartely Rev 1: 77–116

    CAS  Google Scholar 

  • Wistrand PJ (1951) Carbonic anhydrase in the anterior uvea of the rabbit. Acta Physiol Scand 24: 144–148

    Article  Google Scholar 

  • Wistrand PJ, Rawls JA, Maren TH (1960) Sulfonamide carbonic anhydrase inhibitors and intraocular pressure in rabbits. Acta Pharmacol Toxicol 17: 337–355

    Article  CAS  Google Scholar 

  • Wistrand PJ (1961) Sulphonamide carbonic anhydrase inhibitors. Studies with special reference to their ocular effects. Acta Soc Med Upsaliensis 66: 1–12

    CAS  Google Scholar 

  • Wistrand PJ, Rao SN (1968) Immunologic and kinetic properties of carbonic anhydrase from-various tissues. Biochim Biophys Acta 154: 130–144

    Article  PubMed  CAS  Google Scholar 

  • Wistrand PJ, Lindahl S, WĂĄhlstrand T, (1975) Human renal carbonic anhydrase. Purification and properties. Eur J Biochem 57:189–195

    Article  PubMed  CAS  Google Scholar 

  • Wistrand PJ, Kinne R (1977) Carbonic anhydrase activity of isolated brush border and basal-lateral membranes of renal tubular cells. PflĂĽgers Arch 370: 121–130

    Article  PubMed  CAS  Google Scholar 

  • Wistrand PJ, Schenholm M, Lonnerholm G (1986) Carbonic anhydrase isoenzymes CA I and CA II in the human eye. Invest Ophthalmol Vis Sci 27: 419–428

    PubMed  CAS  Google Scholar 

  • Wistrand PJ, Knuuttila K-G (1989) Renal membrane-bound carbonic anhydrase. Purification and properties. Kidney Int 35: 851–859

    Article  PubMed  CAS  Google Scholar 

  • Wolfensberger TJ, Mahieu I, Jarvis-Evans J, Boulton M, Carter ND, Nogradi A, Hollande E, Bird AC (1994) Membrane bound carbonic anhydrase in human retinal pigment epithelium. Invest Ophthalmol Vis Sci 35: 3401–3407

    PubMed  CAS  Google Scholar 

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Wistrand, P.J. (2000). Carbonic anhydrase research: a clinical perspective, past and future. In: Chegwidden, W.R., Carter, N.D., Edwards, Y.H. (eds) The Carbonic Anhydrases. EXS 90, vol 90. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8446-4_31

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  • DOI: https://doi.org/10.1007/978-3-0348-8446-4_31

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9570-5

  • Online ISBN: 978-3-0348-8446-4

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