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The Carbonic Anhydrases pp 569–596Cite as

Birkhäuser

Keeping pace with a fast enzyme: steps and missteps

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Part of the book series: EXS 90 ((EXS,volume 90))

Abstract

I have often been asked why I have worked primarily on one enzyme system throughout my research career. The following reminiscences of some episodes in carbonic anhydrase (CA) research in which our laboratory was directly or indirectly involved, should provide some answers. Above all, it has been the rather steady stream of challenging and often unexpected findings on the structure, genetics, function, expression and evolution of the carbonic anhydrases (in both their active and inactive forms) that has rekindled my obsession with this one enzyme over and over. Since it would not be possible to include all of the experiences with CA that I have encountered over the past 35 years or so, I have predictably agonized over those that I thought worth relating; however, please bear with me for dwelling, perhaps excessively at times, over matters of a more personal nature.

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Authors and Affiliations

  1. Department of Human Genetics, University of Michigan Medical School, Medical Science II, M4708, Ann Arbor, MI, 48109, USA

    Richard E. Tashian

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  1. Richard E. Tashian
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Editors and Affiliations

  1. Lake Erie College of Osteopathic Medicine, 1858 West Grandview Boulevard, Erie, PA, 16509, USA

    W. Richard Chegwidden

  2. Medical Genetics Unit, St George’s Hospital Medical School, London, SW17 0RE, UK

    Nicholas D. Carter

  3. MRC Human Biochemical Genetics Unit, Wolfson House, University College London, 4, Stephenson Way, London, NW1 2HE, UK

    Yvonne H. Edwards

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Tashian, R.E. (2000). Keeping pace with a fast enzyme: steps and missteps. In: Chegwidden, W.R., Carter, N.D., Edwards, Y.H. (eds) The Carbonic Anhydrases. EXS 90, vol 90. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8446-4_30

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  • DOI: https://doi.org/10.1007/978-3-0348-8446-4_30

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9570-5

  • Online ISBN: 978-3-0348-8446-4

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