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The design of new carbonic anhydrase inhibitors

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Book cover The Carbonic Anhydrases

Part of the book series: EXS 90 ((EXS,volume 90))

Abstract

Soon after the discovery of carbonic anhydrase (CA) (Meldrum and Roughton, 1932) it was shown by Mann and Keilin (1940) that certain sulfonamides were specific and potent inhibitors of this enzyme. Since then various arene-and heteroarene-sulfonamides have been synthesised and evaluated (Maren, 1967, 1974) as inhibitors of carbonic anhydrase for possible therapeutic use as anticonvulsants (Gray et al., 1957; Gray and Rauh, 1967), antiglaucoma agents (Becker, 1954; Friedenwald, 1949), cerebral vasodilators (Barnish et al., 1980; Cross et al., 1978), and diuretics Peters and Roch-Ramel, 1969).

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Authors and Affiliations

  1. Krebs Institute, Department of Chemistry, University of Sheffield, Sheffield, S3 711F, UK

    Umar F. Mansoor, Xiu-Rong Zhang & G. Michael Blackburn

Authors
  1. Umar F. Mansoor
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  2. Xiu-Rong Zhang
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  3. G. Michael Blackburn
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Editors and Affiliations

  1. Lake Erie College of Osteopathic Medicine, 1858 West Grandview Boulevard, Erie, PA, 16509, USA

    W. Richard Chegwidden

  2. Medical Genetics Unit, St George’s Hospital Medical School, London, SW17 0RE, UK

    Nicholas D. Carter

  3. MRC Human Biochemical Genetics Unit, Wolfson House, University College London, 4, Stephenson Way, London, NW1 2HE, UK

    Yvonne H. Edwards

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© 2000 Springer Basel AG

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Mansoor, U.F., Zhang, XR., Blackburn, G.M. (2000). The design of new carbonic anhydrase inhibitors. In: Chegwidden, W.R., Carter, N.D., Edwards, Y.H. (eds) The Carbonic Anhydrases. EXS 90, vol 90. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8446-4_22

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  • DOI: https://doi.org/10.1007/978-3-0348-8446-4_22

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9570-5

  • Online ISBN: 978-3-0348-8446-4

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