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Neuropeptides in drug research

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Progress in Drug Research

Part of the book series: Progress in Drug Research ((PDR,volume 54))

Summary

Neuropeptides have been a subject of considerable interest in the pharmaceutical industry over the last 20 years or more. Many drug discovery teams have contributed to our understanding of neuropeptide biology but no significant drugs that act selectively upon neuropeptide receptors have yet emerged from the clinic. There are, however, a plethora of clinically useful drugs that act at other classes of neurotransmitter and neuromodulator receptors, many of them discovered over the last 20 years. Nevertheless, we think that the future for the discovery of novel drugs acting at neuropeptide receptors looks bright for two reasons: (1) there has been a substantial increase in our understanding of the function of neuropeptides; and (2) high-throughput screening (HTS) against neuropeptide receptors has now begun to yield many interesting drug-like molecules, rather than peptides, that have the potential to become clinically useful drugs.

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Authors and Affiliations

  1. Aston University, Pharmaceutical and Biological Sciences, Aston Triangle, Birmingham, B4 7ET, UK

    David Poyner

  2. Centre for Neuroscience, King’s College London, GKT School of Biomedical Sciences, St Thomas’ Campus, Lamberth Palace Road, London, SE1 7EH, UK

    Helen Cox

  3. Cambridge Drug Discovery Ltd., Cambridge Science Park, Milton Road, Cambridge, CB4 OFG, UK

    Mark Bushfield, J. Mark Treherne & Melissa K. Demetrikopoulos

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  2. Helen Cox
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  5. Melissa K. Demetrikopoulos
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  1. Steinweg 28, Ettingen, CH-4107, Switzerland

    Ernst Jucker

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Poyner, D., Cox, H., Bushfield, M., Treherne, J.M., Demetrikopoulos, M.K. (2000). Neuropeptides in drug research. In: Jucker, E. (eds) Progress in Drug Research. Progress in Drug Research, vol 54. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8391-7_4

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