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Functional roles of postjunctional muscarinic M2 receptors in airway smooth muscle

  • Chapter
Book cover Muscarinic Receptors in Airways Diseases

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Acetylcholine, the main neurotransmitter of the parasympathetic nervous system, acts by binding to two major receptor types, the nicotinic and the muscarinic receptor classes. Muscarinic receptors are composed of five subtypes, M1—M5, encoded by intronless genes, with endogenously expressed correlates in several tissues, including the respiratory tract [1]. Given this diversity, it has been a challenge to define the physiological roles for each subtype. As discussed below, a paucity of selective ligands remains for use as defining pharmacological tools, but gene-targeting techniques, such as receptor antisense and transgenic animals, could assist in this respect. While the antisense techniques have not met with much success in the examination of smooth muscle function, it is fair to state that this has not been exten-sively studied. Alternatively, transgenic mice, lacking muscarinic M1, M2, M4 or M5 receptor genes, have now been constructed but, as yet, no studies have been reported relating to airway smooth muscle function.

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Authors and Affiliations

  1. DiscoveRx Corp, 42501 Albrae St., Fremont, CA, 94538, USA

    Richard M. Eglen

  2. Department of Pharmacology, University of Virginia, 5316 Jordan Hall, 1300 Jefferson Park Ave., Charlottesville, VA, 22908, USA

    Nikki Watson

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Editors and Affiliations

  1. Dept. of Molecular Pharmacology, University of Groningen, A. Deusinglaan 1, Groningen, 9713 AV, The Netherlands

    Johan Zaagsma  & Herman Meurs  & 

  2. Department of Research Management, Pharma Bio-Research Group B.V., P.O. Box 200, 9470 AE, Zuidlaren, The Netherlands

    Ad F. Roffel

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Eglen, R.M., Watson, N. (2001). Functional roles of postjunctional muscarinic M2 receptors in airway smooth muscle. In: Zaagsma, J., Meurs, H., Roffel, A.F. (eds) Muscarinic Receptors in Airways Diseases. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8358-0_4

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  • DOI: https://doi.org/10.1007/978-3-0348-8358-0_4

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