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Identification, localization and function of muscarinic receptor subtypes in the airways

  • Chapter
Muscarinic Receptors in Airways Diseases

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Muscarinic receptors are prominently involved in the control of airway calibre, robustly mediating contraction of airway smooth muscle and secretion of mucus upon activation of the cholinergic nervous system. In line with these responses, autoradiography has visualized muscarinic receptors in extra-and intrapulmonary airway smooth muscle as well as in submucosal glands of both animal and man [1-6]. In addition, these studies identified muscarinic receptor binding sites on airway (parasympathetic) nerves and ganglia of cow and man [3,4,7] and on nerves of pig [6], on airway epithelium of ferret and guinea pig [1,4] but not man [3,4], on pulmonary blood vessels of ferret but not man and pig [1,3,6], as well as on alveolar walls of man, rabbit and pig [4—6] but not ferret and guinea pig [1,4]. The relevance, with respect to the regulation of airway calibre, of muscarinic receptors in these additional locations has not been fully clarified yet, especially regarding the alveolar site.

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Authors and Affiliations

  1. Department of Research Management, Pharma Bio-Research Group B.V., P.O. Box 200, 9470 AE, Zuidlaren, The Netherlands

    Ad F. Roffel

  2. Department of Molecular Pharmacology, University of Groningen, A. Deusinglaan 1, Groningen, 9713 AV, The Netherlands

    Herman Meurs & Johan Zaagsma

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  1. Ad F. Roffel
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  1. Dept. of Molecular Pharmacology, University of Groningen, A. Deusinglaan 1, Groningen, 9713 AV, The Netherlands

    Johan Zaagsma  & Herman Meurs  & 

  2. Department of Research Management, Pharma Bio-Research Group B.V., P.O. Box 200, 9470 AE, Zuidlaren, The Netherlands

    Ad F. Roffel

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Roffel, A.F., Meurs, H., Zaagsma, J. (2001). Identification, localization and function of muscarinic receptor subtypes in the airways. In: Zaagsma, J., Meurs, H., Roffel, A.F. (eds) Muscarinic Receptors in Airways Diseases. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8358-0_3

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  • DOI: https://doi.org/10.1007/978-3-0348-8358-0_3

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