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TGF-β and Related Cytokines in Inflammation pp 11–40Cite as

Birkhäuser

Signal transduction mechanisms for members of the TGF-β family

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

The transforming growth factor-β (TGF-β) superfamily consists of about 30 mammalian members, including TGF-β isoforms, activins, bone morphogenetic proteins (BMPs), Müllerian inhibiting substance (MIS) and others (reviewed by [1]). These factors regulate cell growth, differentiation and apoptosis of various cell types, and have important functions during the embryonal development. TGF-β isoforms inhibit the growth of most cell types, including epithelial cells, endothelial cells and lymphocytes; however, the growth of certain connective tissue cells is stimulated. TGF-β also causes an accumulation of extracellular matrix molecules, via stimulation f synthesis as well as inhibition of degradation, and triggers the IgA class switch of B lymphocytes. Activins stimulate the secretion of follicle stimulating hormone secretion from pituitary cells, promote differentiation of erythropoietic cells and survival of neuronal tissue, and induce dorsal mesoderm in Xenopus embryos. BMPs induce bone and cartilage in vivo, affect the differentiation of hematopoietic stem cells and neural cells, and induce ventral mesoderm in Xenopus. Overactivity or loss of activity of members of the TGF-β family has been implicated in certain disorders, including fibrotic conditions, rheumatoid arthritis and cancer.

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Authors and Affiliations

  1. Ludwig Institute for Cancer Research, Biomedical Center, Box 595, S-751 24, Uppsala, Sweden

    Carl-Henrik Heldin, Aristidis Moustakas & Serhiy Souchelnytskyi

  2. Antoni van Leeuwenhoek Hospital, Division of Cellular Biochemistry, H3, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands

    Susumu Itoh & Peter ten Dijke

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  1. Carl-Henrik Heldin
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  2. Aristidis Moustakas
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  3. Serhiy Souchelnytskyi
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  4. Susumu Itoh
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  5. Peter ten Dijke
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  1. Centre for Immunology, St. Vincent’s Hospital & University of NSW, Victoria St., Sydney, NSW, 2010, Australia

    Samuel N. Breit

  2. Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research National Institutes of Health, 30 Convent Drive, Bethesda, MD, 20878-4352, USA

    Sharon M. Wahl

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Heldin, CH., Moustakas, A., Souchelnytskyi, S., Itoh, S., ten Dijke, P. (2001). Signal transduction mechanisms for members of the TGF-β family. In: Breit, S.N., Wahl, S.M. (eds) TGF-β and Related Cytokines in Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8354-2_2

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  • DOI: https://doi.org/10.1007/978-3-0348-8354-2_2

  • Publisher Name: Birkhäuser, Basel

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