Skip to main content
SpringerLink
Log in

MIC-1 and other TGF-β superfamily members in inflammation

  • Chapter
TGF-β and Related Cytokines in Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

  • 149 Accesses

Abstract

The TGF-β superfamily consists of an expanding number of structurally similar proteins which have been implicated in the regulation of a variety of cellular processes such as growth, motility, and differentiation. Members of the TGF-β superfamily have been classified into major family groupings on the basis of homologies within a seven cysteine domain which encompasses most of the mature protein [1–4]. These include TGF-β, bone morphogenetic protein (BMP), growth and differentiation factor (GDF), inhibin-b/activin (inhB), inhibin-α (inhA), mullerian inhibitory substance (MIS), and glial derived neurotrophic factor (GDNF). The highly characteristic secondary and tertiary structure of TGF-β superfamily proteins occurs within the seven cysteine domain [1–4], even though the level of sequence homology between disparate family members can be low [5], The knotted structure generated by the highly conserved pattern and spacing of cysteine residues leads to dimeric proteins of remarkable stability. This highly conserved structure also makes it relatively simple to identify new members of this superfamily.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ozkaynak E, Schnegelsberg P, Jin D, Clifford G, Warren F, Drier E, Opperman H (1992) Osteogenic protein-2 A new member of the transforming growth factor-β superfamily expressed early in embryogenesis. J Biol Chem 267: 25220–25227

    PubMed  CAS  Google Scholar 

  2. Burt DW, Law AS (1994) Evolution of the transforming growth factor-β superfamily. Progr Growth Factor Res 5: 99–118

    Article  CAS  Google Scholar 

  3. Kingsley DM (1994) The TGF-β superfamily: new members, new receptors and new genetic tests of function in different organisms. Genes Develop 8: 133–146

    Article  PubMed  CAS  Google Scholar 

  4. McPherron A, Lee S (1993) GDF-3 and GDF-9: Two new members of the transforming growth factor-β superfamily containing a novel pattern of cysteines. J Biol Chem 268: 3444_3449

    PubMed  Google Scholar 

  5. Bootcov MR, Bauskin A, Valenzuela SM, Moore AG, Bansal M, He C, Zhang HP, Don-nellan M, Mahler S, Pryor K et a1 (1997) MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily cluster. Proc Natl Acad Sci USA 94: 11514–11519

    Article  PubMed  CAS  Google Scholar 

  6. Fairlie WD, Moore AG, Bauskin AR, Russell PK, Zhang H-P, Breit SN (1999) MIC-1 is a novel TGF-β superfamily cytokine associated with macrophage activation. J Leukocyte Biol 65: 2–5

    PubMed  CAS  Google Scholar 

  7. Yokoyama-Koyabashi M, Saeki M, Sekine S, Kato S (1997) Human cDNA encoding a novel TGF-β superfamily protein highly expressed in placenta. J Biochem 122: 622–626

    Article  Google Scholar 

  8. Roberts AB, Sporn MB (1993) Physiological actions and clinical applications of transforming growth factor-β (TGF-β). Growth Factors 8: 1–9

    Article  PubMed  CAS  Google Scholar 

  9. Lawton LN, de Fatima Bonaldo M, Jelenc PC, Qiu L, Baumes SA, Marcelino RA, De Jesus GM, Wellington S, Knowles JA, Warburton D et al (1997) Identification of a novel member of the TGF-β superfamily highly expressed in human placenta. Gene 203: 17–26

    Article  PubMed  CAS  Google Scholar 

  10. Bauskin AR, Zhang H-P, Fairlie WD, He XY, Russell P, Moore AG, Brown D, Stanley KK, Breit SN (2000) The propeptide of macrophage inhibitory cytokine (MIC-l), a TGF-β superfamily member acts as a quality control determinant for correctly folded MIC-l. EMBO J 19: 2212–2220

    Article  PubMed  CAS  Google Scholar 

  11. Assoian RK, Fleurdelys BE, Stevenson HC, Miller PJ, Madtes DK, Raines EW, Ross R, Sporn MB (1987) Expression and secretion of type beta transforming growth factor by activated human macrophages. Froc Natl Acad Sci USA 84: 6020–6024

    Article  CAS  Google Scholar 

  12. Grotendorst GR, Smale G, Pencev D (1989) Production of transforming growth factorb by human peripheral blood monocytes and neutrophils. J Cell Fhysiol 140: 396–402

    Article  CAS  Google Scholar 

  13. Nishihara T, Ohsaki Y, Ueda N, Koseki T, Eto Y (1995) Induction of apoptosis in B lineages by activin-A derivered from macrophages. J Interferon Cytokine Res 15: 509–516

    Article  PubMed  CAS  Google Scholar 

  14. Yu J, Shao YJ, Frigon NL, Logren J, Schwall R (1996) Induced expression of the new cytokine, activin A, in human monocytes: inhibition by glucocorticoids and retinoic acid. Immunol 88: 368–374

    Article  CAS  Google Scholar 

  15. Shao L, Frigon NL, Sehy DW, Yu AL, Lofgren J, Schwall R, Yu J (1992) Regulation of production of activin-A in human marrow stromal cells and monocytes. Exp Hematol 20:1235–1242

    PubMed  CAS  Google Scholar 

  16. Tsunawaki S, Sporn M, Ding Am, Nathan C (1988) Deactivation of macrophages by transforming growth factor-beta. Nature 334: 260–262

    Article  PubMed  CAS  Google Scholar 

  17. Bogdan C, Nathan C (1993) Modulation of macrophage function by transforming growth factor beta, IL-4 and IL-10. Annal NY Acad Sci 685: 713–739

    Article  CAS  Google Scholar 

  18. Shull MM, Ormsby I, Kier AB, Pawlowski S, Diebold RJ, Yin M, Allen R, Sidman C, Proetzel G, Calvin D et al (1992) Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359: 693–699

    Article  PubMed  CAS  Google Scholar 

  19. Drouin SM, Kiley SC, Carlino JA, Barnum SR (1998) Transforming growth factor-β2 regulates C3 secretion in monocytes through a protein kinase C-dependant pathway. Molec Immunol 35: 1–11

    CAS  Google Scholar 

  20. Yamashita N, Nakajima N, Takahashi H, Kaneoka H, Mizushima Y, Sakane T (1993) Effects of activin-A on IgE synthesis and cytokine production by human peripheral mononuclear cells. Clin Exp Immunol 94: 214–219

    Article  PubMed  CAS  Google Scholar 

  21. Kozaki K, Akishita M, Eto M, Yoshizumi M, Toba K, Inoue S, Ishikawa M, Hashimo-to T, Yamada N, Orimo H et al (1997) Role of activin-A and follistatin in foam cell formation of THP-1 macrophages. Arterioscler Thromb Vasc Biol 17: 2389–2394

    Article  PubMed  CAS  Google Scholar 

  22. Nusing RM, Mohr S, Ullrich V (1995) Activin-A and retinoic acid synergise in cyclooxygenase-1 and thromboxane synthase induction during differentation of J7741 macrophages. Eur J Biochem 222: 130–136

    Article  Google Scholar 

  23. Hilden K, Tuuri T, Eramaa M, Ritvos O (1994) Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activn receptor. Blood 83: 2163–2170

    PubMed  CAS  Google Scholar 

  24. Brandes ME, Wakefield LM, Wahl SM (1991) Modulation of monocyte type 1 transforming growth factor beta receptors by inflammatory stimuli. J Biol Chem 266: 19697–19703

    PubMed  CAS  Google Scholar 

  25. Walker DG, Beach TG, Xu R, Lile J, Beck KD, McGeer EG, McGeer PL (1998) Expression of the proto-oncogene Ret, a component of the GDNF receptor complex, persists in human substantia nigra neurons in Parkinson’s disease. Brain Res 792: 207–217

    Article  PubMed  CAS  Google Scholar 

  26. Petraglia F, Sacerdote P, Cossarizza A, Angioni S, Genazzani AD, Franceschi C, Muscettola M, Grasso G (1991) Inhibin and activin modulate human monocyte Chemotaxis and human lymphocyte interferon-gamma production. J Clin Endocrinol Metab 72: 496–502

    Article  PubMed  CAS  Google Scholar 

  27. Postlethwaite AE, Raghow R, Stricklin G, Ballou L, Sampath TK (1994) Osteogenic protein-1, a bone morphogenic protein member of the TGF-β superfamily, shares chemotactic but not fibrogenic properties with TGF-β. J Cell Physiol 161: 562–570

    Article  PubMed  CAS  Google Scholar 

  28. Wahl SM (1994) Transforming growth factor-β: The good, the bad and the ugly. J Exp Med 180:1587–1590

    Article  PubMed  CAS  Google Scholar 

  29. Cunningham NS, Paralkar V, Reddi AH (1992) Osteogenin and recombinant BMP-2B are chemotatic for human monocytes and stimulate TGF-β1 expression. Proc Natl Acad Sci USA 89: 11740–11744

    Article  PubMed  CAS  Google Scholar 

  30. Hromas R, Hufford M, Sutton J, Xu D, Li Y, Lu L (1997) PLAB, a novel placental bone morphogenetic protein. Bioehim Biophys Acta 1354: 40–44

    Article  CAS  Google Scholar 

  31. Jacobsen FW, Stokke T, Jacobsen SEW (1995) Transforming growth factor-β potently inhibits the viability-promoting activity of stem cell factor and other cytokines and induces apoptosis of primitive murine hematopoietic progenitor cells. Blood 86: 2957–2966

    PubMed  CAS  Google Scholar 

  32. Johansson BM, Wiles MV (1995) Evidence for involvement of activin A and bone morphogenetic protein-4 in mammalian mesoderm and hematopoietic development. Mol Cellular Biol 15: 141–151

    CAS  Google Scholar 

  33. Yamada R, Suzuki T, Hashimoto M, Eto Y, Shiokawa K, Muramatsu M (1992) Induction of differentiation of the human promyelocytic cell line HL-60 by activin/EDF. Biochem Biophys Res Comm 187: 79–85

    Article  PubMed  CAS  Google Scholar 

  34. Okabe-Kado J, Honma Y, Hayashi M, Hozumi M (1991) Effects of transforming growth factor-b and activin-A on vitamin D3-induced monocytic differentiation of myeloid leukemia cells. Anticancer Res 11: 181–186

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. St. Vincent’s Hospital and University of NSW, Centre for Immunology, Victoria St., Sydney, NSW, 2010, Australia

    Anthony G. Moore, W. Douglas Fairlie, Asne R. Bauskin, Peter K. Brown, Patricia K. Russell, Hong-Ping Zhang & Samuel N. Breit

Authors
  1. Anthony G. Moore
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. Douglas Fairlie
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Asne R. Bauskin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Peter K. Brown
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Patricia K. Russell
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hong-Ping Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Samuel N. Breit
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Centre for Immunology, St. Vincent’s Hospital & University of NSW, Victoria St., Sydney, NSW, 2010, Australia

    Samuel N. Breit

  2. Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research National Institutes of Health, 30 Convent Drive, Bethesda, MD, 20878-4352, USA

    Sharon M. Wahl

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer Basel AG

About this chapter

Cite this chapter

Moore, A.G. et al. (2001). MIC-1 and other TGF-β superfamily members in inflammation. In: Breit, S.N., Wahl, S.M. (eds) TGF-β and Related Cytokines in Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8354-2_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-8354-2_1

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9531-6

  • Online ISBN: 978-3-0348-8354-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation