Abstract
Transplantation tolerance can be defined as immune unresponsiveness of a recipient toward the donor in the absence of ongoing therapy, yet maintenance of normal immune responsiveness toward other non-self antigens. The first observation of an animal immunologically tolerant to cells of another individual was made by Owen [1] in studying blood group chimerism which he noted in dizygotic cattle twins (Fig. 1). He explained the stable presence of two blood groups in each twin based on the knowledge that they shared common placental circulation in utero (Fig. 2). In other words, the exposure of one twin to the other’s different blood group during fetal life had led to persistence of these blood group progenitors into adult life and hence immunologic tolerance of the other’s blood group antigens. This seminal observation formed the first building block in our understanding of transplantation tolerance.
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Knechtle, S.J., Hamawy, M.M. (2001). Tolerance induction. In: Schuurman, HJ., Feutren, G., Bach, JF. (eds) Modern Immunosuppressives. Milestones in Drug Therapy MDT. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8352-8_9
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DOI: https://doi.org/10.1007/978-3-0348-8352-8_9
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