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Gene therapy approaches to immunosuppression

  • Chapter
Modern Immunosuppressives

Part of the book series: Milestones in Drug Therapy MDT ((MDT))

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Abstract

Gene therapy is defined as the delivery of genetic material in the form of DNA. Its purpose is to correct a missing or disturbed gene function associated with a pathophysiological situation in patients. It is attractive compared to the conventional pharmacological therapy, as it can be applied more locally and thus should have fewer side-effects. Somatic gene therapy, the delivery of genetic material in a non-hereditary fashion to mostly an adult target tissue has been persued by the research community for the past 10 years with only moderate success. The methodology of gene therapy must be improved before it becomes a clinical reality. This is in terms of improved efficiency of gene transfer to the target tissue, as well as in tighter control of gene expression. The primary focus of gene therapy will be in correcting genetic disorders followed by its application to so far unmet medical needs, e.g., cancer treatment. The present review summarises the progress which has been made in the past several years in the therapeutic area of transplantation and highlights the potential future applications of gene therapy in enhancing graft survival.

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Author information

Authors and Affiliations

  1. Novartis Pharma Ltd., Transplantation Research, WSJ-386/906, P.O. Box, Basel, CH-4002, Switzerland

    Reto A. Gadient, Thomas Bühler, Marcel Luyten & N. Rao Movva

Authors
  1. Reto A. Gadient
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  2. Thomas Bühler
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  3. Marcel Luyten
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  4. N. Rao Movva
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Editor information

Editors and Affiliations

  1. Novartis Pharma AG, USA

    Henk-Jan Schuurman

  2. Novartis Pharma AG, Basel, 4002, Switzerland

    Gilles Feutren

  3. Immunologie Clinique, Hôpital Necker, 161 Rue de Sèvres, Paris Cedex 15, France

    Jean-François Bach

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© 2001 Springer Basel AG

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Gadient, R.A., Bühler, T., Luyten, M., Movva, N.R. (2001). Gene therapy approaches to immunosuppression. In: Schuurman, HJ., Feutren, G., Bach, JF. (eds) Modern Immunosuppressives. Milestones in Drug Therapy MDT. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8352-8_10

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  • DOI: https://doi.org/10.1007/978-3-0348-8352-8_10

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9530-9

  • Online ISBN: 978-3-0348-8352-8

  • eBook Packages: Springer Book Archive

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