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Proinflammatory actions of derivatives of the β amyloid precursor protein

  • Chapter
Neuroinflammatory Mechanisms in Alzheimer’s Disease Basic and Clinical Research

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

The first genetic lesions associated with Alzheimer’s disease were in the coding sequence of the β amyloid precursor protein (βAPP) [1]. Although these mutations account for a small proportion of familial Alzheimer (FAD) cases, they conceptually solidified the link between this protein and the pathology of the disease. As the source of the amyloid β peptide (Aβ) that accumulates in plaques, βAPP had garnered attention for several years. The mutations were immediately presumed to contribute to disease by modifying Aβ production, but increased understanding of the bioactivities of βAPP itself have led to models that do not depend on Aβ for Alzheimer pathogenesis. Both Aβ and non-amyloidogenic derivatives of βAPP can have an impact on proinflammatory glial activation. Indeed, the role of inflammatory reactions in Alzheimer’s has been lent additional credence by indications of such reactions in mice transgenic for βAPP. These interactions will be reviewed and discussed here in the context of cell biology; protein-protein interactions between Aβ and α2-macroglobulin or components of the complement cascade are addressed in accompanying chapters of this volume.

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  1. Departments of Geriatrics, Anatomy, and Internal Medicine, University of Arkansas for Medical Sciences; Geriatric Research Education Clinical Center, Central Arkansas Veterans Healthcare System, Little Rock, AR, 72205, USA

    Steven W. Barger

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  1. Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ, 85372, USA

    Joseph Rogers

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Barger, S.W. (2001). Proinflammatory actions of derivatives of the β amyloid precursor protein. In: Rogers, J. (eds) Neuroinflammatory Mechanisms in Alzheimer’s Disease Basic and Clinical Research. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8350-4_8

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  • DOI: https://doi.org/10.1007/978-3-0348-8350-4_8

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9529-3

  • Online ISBN: 978-3-0348-8350-4

  • eBook Packages: Springer Book Archive

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