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Recombinant Protein Drugs pp 67–88Cite as

Birkhäuser

Clotting factors VIII and IX

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Part of the book series: Milestones in Drug Therapy ((MDT))

Abstract

Haemophilia is the most common congenital disorder of coagulation and affects approximately 1 in 10,000 males around the world. Haemophilia A is due to a deficiency of factor VIII in the circulating blood whilst haemophilia B (also known as Christmas disease) is a clinically identical disorder caused by factor IX deficiency. It is less common than haemophilia A and affects 1 in about 30,000 males. Both factors VIII and IX are essential glycoproteins in the clotting cascade [1] (Fig. 1). The hallmark of severe haemophilia is recurrent and spontaneous haemarthrosis, typically affecting the hinge joints such as the ankle, knee and elbow. The severity of bleeding depends upon the level of factor in the blood.

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Author information

Authors and Affiliations

  1. Chemical Pathology Unit, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK

    George G. Brownlee

  2. Oxford Haemophilia Centre, The Churchill Hospital, Oxford, UK

    Paul L. F. Giangrande

Authors
  1. George G. Brownlee
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  2. Paul L. F. Giangrande
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Editors and Affiliations

  1. Xantos Biomedicine, Fraunhoferstr. 22, Martinsried, D-82152, Germany

    Peter Buckel

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© 2001 Springer Basel AG

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Brownlee, G.G., Giangrande, P.L.F. (2001). Clotting factors VIII and IX. In: Buckel, P. (eds) Recombinant Protein Drugs. Milestones in Drug Therapy. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8346-7_3

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  • DOI: https://doi.org/10.1007/978-3-0348-8346-7_3

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9527-9

  • Online ISBN: 978-3-0348-8346-7

  • eBook Packages: Springer Book Archive

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