Abstract
Debra Martin was visiting the Calcified Tissue Laboratory at Henry Ford Hospital in Detroit, Michigan, learning to make thin sections of undecalcifiedtarchaeological bone. The objective of her visit was to make slides of bone thin enough to allow the light from the microscope to be transmitted through them. Although modern equipment speeds up the process, Martin, at the time a graduate student at the University of Massachusetts, was using a manual method for grinding the bone to the desired 100-micron thickness. The femoral cross-section is removed from an area just below the lesser trochanter (a few inches below its neck).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Strouhal E (1977) The physical anthropology of the Meroitic area. Third International Meroitic Conference, Toronto, Canada, 1977
Adams WY (1967) Continuity and change in Nubian culture history. Sudan Notes and Records 48: 1–32
Adams WY (1977)Nubia: Corridor to Africa.Princeton: Princeton University Press
Bassett EJ, Keith MS, Armelagos GJ, Martin DL, VillanuevaA (1980) Tetracycline-labeled human bone from ancient Sudanese Nubia (A.D. 350).Science209: 1532–1534
Hummert JR, VanGerven DP (1982) Tetracycline-labeled human bone from a medieval population in Nubia’s Batn el Hajar (550–1450 A. D.).Hum Biol54: 355–371
Keith M, Armelagos GJ (1981) Naturally occurring dietary antibiotics and human health. In: L Romannuci-Ross, D Moerman, RR Tancreddi (eds):The Anthropology of Medicine 1st ed. Preager Press, New York
Keith M, Armelagos GJ (1983) Naturally occurring dietary antibiotics and human health. In: L Romannuci-Ross, D Moerman, RR Trancreddi (eds):The Anthropology of Medicine.Preager Press, New York
Ortner DJ, Putschar WGJ (1981)Identification of Pathological Conditions in Human Skeletal RemainsVol 28. Smithsonian Institution Press, Washington D.C.
Cook M, Molto EL, Anderson C (1989) Fluorochrome labelling in Roman Period skeletons from Dakhleh Oaisis, Egypt.Amer J Phys Anthropol80: 137–143
Keith M, Armelagos GJ (1988) An example ofin vivotetracycline labelling: reply to Piepenbrink.J Archaeol Sci15: 595–601
Cook JA (1998) Tetracycline labeling in an ancient Nubian X-Group (24-I-3) population. Senior Honors, Emory University
Piepenbrink H (1986) Two examples of biogenous dead bone decomposition and their consequences for taphonomic interpretation.J Archaeol Sci13: 417–430
Piepenbrink H, Herrmann B, Hoffmann P (1981) Tetracyclintypische Fluoreszenzen an bodengelagerten Skeletteilen.Z Rechtsmedizin91: 71–74
Hackett CJ (1981) Microscopical focal destruction (tunnels) in exhumed human bone.Med Sci Law21: 243–265
Marchiafava V, Bonnucci E, Ascenzi A (1974) Fungal osteoclasia: a model of dead bone resorption.Calcified Tiss Res14: 195–210
Martin D (1983)Paleophysiological Aspects of Bone Remodeling in Meroitic X-Group and Christian Populations from Sudanese Nubia. Doctoral Dissertation, University of Massachusetts, Amherst
Ascenzi A (1963) Microscopy and prehistoric bone. In: DR Brothwell, E Higgs (eds):Science in Archaeology.Thames and Hudson, London, 526–538
Baker BJ (1992)Collagen Composition in human Skeletal Remains from the NAX Cemetery (A.D. 350–550) in Lower Nubia.Doctoral Dissertation, University of Massachusetts, Amherst
Urist MR, Ibsen KH (1963) Chemical reactivity of mineralized tissues with oxytetracycline.Arch Pathol 75:484–496
Waksman SA (1967)The Actinomycetes: A Summary of Current Knowledge.The Ronald Press Company, New York
Alexander M (1977)Introduction to Soil Microbiology.John Wiley and Sons, New York
Williams ST (1982) Are antibiotics produced in soil?Pedobiologia23: 427–435
Howie WJ, Suslow TV (1991) Role of antibiotic biosynthesis in the inhibition ofPythium ultimumin the cotton spermosphere and rhizosphere byPseudomonas fluorescens. Mol Plant Microbe Interact4: 393–399
Darby WJ, Ghalioungui P, Grivetti L (1977)Food: The Gift of Osiris.2 vols. Academic Press, London
Culwick GM (1951) Diet in the Gezira Irrigated Area, Sudan. Khartoum: Sudan Survey Department, No. 304
Cummings LS (1983)Coprolites from Medieval Christian Nubia: An Interpretation of Diet and Nutritional Stress.Doctoral Dissertation, University of Colorado
Kemp BJ (1989)Ancient Egypt: Anatomy of a Civilization.Routledge, London
Mills J (1992) Beyond nutrition: Antibiotics produced through grain storage practices, their recognition and implication for the Egyptian Predynastic. In:R Friedman, B Adams (eds):The Followers of Horus: Studies Dedicated to Michael Allen Hoffman,(1944–1990).Egyptian Studies Association Publication No. 2, Oxbow Monograph 20, 28–35
Frost HM, Villanueva A, Roth H, Stanisavlevic S (1961) Experimental multiband tetracycline measurements of lamellar osteoblastic activity.Henry Ford Hospital Med Bull9: 312–329
Frost HM, Villanueva A, Roth H, Stanisavlevic S (1961) Tetracycline bone labelling.New Drugs1: 206–211
Milch R, Koll DP, Tobie JE (1958) Fluorescence of tetracycline antibiotics in bone.J Bone Joint Surg40A: 897–909
Oklund SA, Prolo DJ, Guittierrez RV (1981) The significance of yellow bone: Evidence for tetracycline in adult human bone.JAMA246: 761–763
Cohlan SQ, Bevelander G, Tiamsic T (1963) Growth inhibition of prematures receiving tetracycline: A clinical and laboratory investigation of tetracycline-induced bone fluorescence.Amer J Dis Child20: 275–290
Demers P, Fraser D, Goldbloom RB, Haworth JC, LaRochelle J, McLean R, Murray TK (1968) Effects of tetracycline on skeletal growth and dentition.Can Med Assn J99: 849–854
Timmermans L (1974) Influence of antibiotics on spermatogenesis.J Urol112: 348–349
Grauer A, Armelagos GJ (1998) Skeletal Biology of Hesban: a biocultural interpretation. In: SD Waterhouse (ed.):The Necropolis of Hesban: A Typology of Tombs. Hesban 10.Andrews University Press, Benin Springs, 107–131
Von Deines H, Grapow H (1959)Wörterbuch der Aegyptischen DrogennamenVol 6. AkadenieVerlag, Berlin
Golub LM, Lee HM, Ryan ME, Giannobile WV, Payne J, Sorsa T (1998) Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms.Adv Dent Res12: 12–26
Golub LM, McNamara TF, D’Angelo G, Greenwald RA, Ramamurthy NS (1987) A non-antibacterial chemically-modified tetracycline inhibits mammalian collagenase activity.J Dent Res66: 1310–1314
Greenwald RA, Golub LM, Lavietes B, Ramamurthy NS, Gruber B, Laskin RS, McNamara TF (1987) Tetracyclines inhibit human synovial collagenasein vivoandin vitro. J Rheumatol14: 28–32
Ramamurthy N, Leung BM, Moak S, Greenwald R, Golub L (1993) CMT/NSAID combination increases bone CMT uptake and inhibit bone resorption.Ann NYAcad Sci696: 420–421
Yu Z, Ramamurthy NS, Leung M, Chang KM, McNamara TF, Golub LM (1993) Chemically-modified tetracycline normalizes collagen metabolism in diabetic rats: a dose-response study.J Periodont Res28: 420–428
de Bri E, Lei W, Svensson O, Chowdhury M, Moak SA, Greenwald RA (1998) Effect of an inhibitor of matrix metalloproteinases on spontaneous osteoarthritis in guinea pigs.Adv Dent Res12: 82–85
Golub L, Greenwald R, Ramamurthy N, Zucker S, Ramsammy L, McNamara T (1992) Tetracyclines (TCs) inhibit matrix metalloproteinases (MMPs):in vivoeffects in arthritic and diabetic rats and newin vitrostudies.Matrix Suppl1: 315–316
Greenwald RA (1994) Treatment of destructive arthritic disorders with MMP inhibitors. Potential role of tetracyclines.Ann NYAcad Sci732: 181–198
Golub LM, Lee HM, Greenwald RA, Ryan ME, Sorsa T, Salo T, Giannobile WV (1997) A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis.Inflamm Res46: 310–319
Greenwald RA, Golub LM, Ramamurthy NS, Chowdhury M, Moak SA, Sorsa T (1998) In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: relationship to bone and cartilage degradation. Bone22: 33–38
Myers SA, Wolowacz RG (1998) Tetracycline-based MMP inhibitors can prevent fibroblast-mediated collagen gel contractionin vitro. Adv Dent Res12: 86–93
Ramamurthy NS, Schroeder KL, McNamara TF, Gwinnett AJ, Evans RT, Bosko C, Golub LM (1998) Root-surface caries in rats and humans: inhibition by a non-antimicrobial property of tetracyclines.Adv Dent Res12: 43–50
Ryan ME, Ramamurthy S, Golub LM (1996) Matrix metalloproteinases and their inhibition in periodontal treatment.Curr Opin Periodontol3: 85–96
Suomalainen K, Halmen S, Ingman T, Lindy O, Saari H, Konttinen YT, Golub LM, Sorsa T (1992) Tetracycline inhibition identifies the cellular sources of collagenase in gingival crevicular fluid in different forms of periodontal diseases.Drug Exp Clin Res18: 99–104
Lauhio A, Salo T, Tjaderhane L, Landevirta J, Golub LM, Sorsa T (1995) Tetracyclines in treatment of rheumatoid arthritis.Lancet346: 645–646
Nordstrom D, Lindy O, Lauhio A, Sorsa T, Santavirta S, Konttinen YT (1998) Anti-collagenolytic mechanism of action of doxycycline treatment in rheumatoid arthritis.Rheumatol Int17: 175–180
Golub LM, Ramamurthy N, McNamara TF, Gomes B, Wolff M, Casino A, Kapoor A, Zambon J, Ciancio S, Schneir M (1984) Tetracyclines inhibit tissue collagenase activity. A new mechanism in the treatment of periodontal disease.J Periodont Res19: 651–655
Dollery CM, McEwan JR, Henney AM (1995) Matrix metalloproteinases and cardiovascular disease. Circ Res 77:863–868
Armelagos GJ, Mielke JH, Owen KH, VanGerven DP, Dewey JR, Mahler PE (1972) Bone growth and development in prehistoric populations from Sudanese Nubia.J Hum Evol 1:89–119
Arnold JS (1960) Quantification of mineralization of bone as an organ and tissue in osteoporosis.Clint Orthopaed49: 167–175
Arnold JS, Bartley MH, Tont SA, Jenkins DP (1965) Skeletal changes in aging and disease.Clint Orthopaed49: 17–38
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer Basel AG
About this chapter
Cite this chapter
Armelagos, G.J., Kolbacher, K., Collins, K., Cook, J., Krafeld-Daugherty, M. (2001). Tetracycline consumption in prehistory. In: Nelson, M., Hillen, W., Greenwald, R.A. (eds) Tetracyclines in Biology, Chemistry and Medicine. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8306-1_9
Download citation
DOI: https://doi.org/10.1007/978-3-0348-8306-1_9
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-9511-8
Online ISBN: 978-3-0348-8306-1
eBook Packages: Springer Book Archive