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Interactions of tetracyclines with RNA

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Tetracyclines in Biology, Chemistry and Medicine

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Abstract

The tetracyclines (Fig. 1) are secondary metabolites produced by Gram-positive bacteria from the generaStreptomycesorNocardia.They act as antibiotics and inhibit protein biosynthesis by interfering with binding of the aminoacyltRNA-EF-Tu-GTP ternary complex to the ribosomal A-site [1].

Gram-positive bacteria, cell wall free mycoplasmas, rickettsiae, chlamydiae and protozoan parasites.

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  1. Lehrstuhl für Mikrobiologie, Institut für Mikrobiologie, Biochemie und Genetik, Friedrich-Alexander Universität Erlangen-Nürnberg, Staudtstr, Erlangen, 5, D-91058, Germany

    Christian Berens

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  1. Paratek Pharmaceuticals, 75 Kneeland St., Boston, MA, 02111, USA

    Mark Nelson

  2. Lehrstuhl für Mikrobiologie, Friedrich-Alexander Universität, Erlangen-Nürnberg Staudstr. 5, Erlangen, D-91058, Germany

    Wolfgang Hillen

  3. Division of Rheumatology, Long Island Jewish Medical Center, Suite 107 410 Lakeville Rd, New Hyde Park, NY, 11040, USA

    Robert A. Greenwald

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Berens, C. (2001). Interactions of tetracyclines with RNA. In: Nelson, M., Hillen, W., Greenwald, R.A. (eds) Tetracyclines in Biology, Chemistry and Medicine. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8306-1_7

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  • DOI: https://doi.org/10.1007/978-3-0348-8306-1_7

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