Abstract
Tetracyclines are a family of broad-spectrum antibiotics which have been used for decades to treat a variety of infections. Tetracyclines also have numerous non-antimicrobial properties which make them attractive for the treatment of inflammatory disorders and cancer. These include the ability to inhibit matrix metalloproteinases (MMPs), serine proteases, and various inflammatory cytokines such as TNF-a, iNOS, and PLA2(reviewed in [1]). The clinical value of the tetracyclines as antibiotics is enhanced by their low toxicity during short-term administration. However, the treatment of chronic disorders such as inflammation and cancer can require long-term, if not life-long treatment. This type of prolonged use of tetracyclines can be associated with certain treatment obstacles such as the emergence of antibiotic-resistant flora, gastrointestinal upset, photosensitivity and related skin disorders, all of which can put constraints on the administered dose. To circumvent obstacles associated with the development of microbial resistance and the normal balance of the GI flora, a series of chemically modified tetracyclines (CMTs) have been developed that lack anti-microbial activity but retain anti-inflammatory and anti-cancer activity. However, the chemical modifications that affect the antimicrobial activities of the tetracycline family do not necessarily translate into reduced photosensitivity. Therefore, phototoxicity may still limit the therapeutic potential of the non-antimicrobial CMTs.
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Zerler, B.R. (2001). Tetracycline photodynamics. In: Nelson, M., Hillen, W., Greenwald, R.A. (eds) Tetracyclines in Biology, Chemistry and Medicine. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8306-1_15
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DOI: https://doi.org/10.1007/978-3-0348-8306-1_15
Publisher Name: Birkhäuser, Basel
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