Abstract
Tetracyclines (TCs) are a group of antibiotic compounds which possess anti-inflammatory activity bothin vivoandin vitroat pharmacological concentrations. They inhibit the activity of pleiotropic inflammatory mediators such as nitric oxide, prostaglandins, cytokines and MMPs. The mechanism of action of this group of compounds, to inhibit various inflammatory mediators is distinctive. TCs and chemically modified TCs (CMTs) both inhibit nitric oxide synthase (mRNA level), TNFa convertase (enzyme level), which subsequently downregulates nitric oxide, and TNFa production, respectively. TCs and CMTs modulate anti-inflammatory mediators such as IL-10 (mRNA level) and type II IL-1P decoy receptor (secretory enzyme level). Doxycycline and minocycline augment COX-2 (mRNA level)-mediated PGE2production, whereas CMTs preferentially inhibit COX-2 both at mRNA and protein level. These pleiotropic properties of TCs and CMTs make them candidate drugs for complex multifactoral inflammatory diseases.
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Attur, M.G., Dave, M.N., Mohandas, N., Patel, I.R., Abramson, S.B., Amin, A.R. (2001). Regulation of inflammatory mediators by tetracyclines. In: Nelson, M., Hillen, W., Greenwald, R.A. (eds) Tetracyclines in Biology, Chemistry and Medicine. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8306-1_13
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DOI: https://doi.org/10.1007/978-3-0348-8306-1_13
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