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Inflammation and Stroke pp 101–111Cite as

Birkhäuser

Inflammatory activation of brain cells by hypoxia: transcription factors and signaling pathways

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Cytokines play a major role in the initiation, propagation, regulation and suppression of inflammatory responses [1–3]. Most cells do not constitutively express cytokines, but rather an activation event results in cytokine gene transcription. The major intrinsic sources of cytokines in the brain are glial cells [1>]. However, elements of the brain vasculature including cerebral endothelial cells (CEC), pericytes, and perivascular macrophages, as well as peripheral immune cells that infiltrate the brain in pathological states, are significant sources of cytokines [1–4].

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Author information

Authors and Affiliations

  1. Institute for Biological Sciences, National Research Council of Canada, Montreal Road Campus, Bldg. M-54, Ottawa, ON, K1A OR6, Canada

    Danica B. Stanimirovic

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  1. Danica B. Stanimirovic
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Editor information

Editors and Affiliations

  1. Cardiovascular Diseases Research Experimental Station, DuPont Pharmaceuticals Company, Route 141 & Henry Clay Road, Wilmington, DE, 19880, USA

    Giora Z. Feuerstein

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© 2001 Springer Basel AG

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Stanimirovic, D.B. (2001). Inflammatory activation of brain cells by hypoxia: transcription factors and signaling pathways. In: Feuerstein, G.Z. (eds) Inflammation and Stroke. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8297-2_9

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  • DOI: https://doi.org/10.1007/978-3-0348-8297-2_9

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9508-8

  • Online ISBN: 978-3-0348-8297-2

  • eBook Packages: Springer Book Archive

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