Abstract
The association of preceding systemic infection and ischemic stroke has long been recognized by clinicians [1–7]. In a retrospective study of ischemic stroke in Sweden, stroke incidence exhibited seasonal variability with higher incidence in the colder winter months [1]. Infection was suggested to underlie the increased stroke incidence during winter since, in young adults without established stroke-risk factors, evidence of infection was seen concomitantly with the onset of stroke [1>]. Seasonal variability of plasma fibrinogen and factor VII activity in an elderly population in England with increased levels during winter was also related to respiratory infections [8]. Syrjanen et al. [4] demonstrated in Finland that young to middle-aged patients presenting with acute ischemic stroke had a significantly higher prevalence of febrile infections 1 month preceding the stroke. A similar association of ischemic stroke and dental infection in the preceding month was further established in young Finnish men [9]. Evidence of infection less than 1 month before onset of stroke was also reported in 34% of stroke patients of all age groups in southern California by Ameriso et al. [10]. Several case-control studies that have also included older patients, revealed that infection within 1 week before onset of stroke or examination was significantly more common among stroke patients than in control subjects [5–7]. An inflammatory response may also explain why chronic infection with Chlamydia pneumoniae is a predisposing risk factor for carotid atherosclerosis and cerebrovascular disease [11–16].
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References
Hindfelt B, Nilsson O (1977) Brain infarction in young adults (with particular reference to pathogenesis). Acta Neurol Scand 55: 145–157
Ode B, Cronberg S (1976) Infection and intracranial arterial thrombosis [letter]. Lancet 2: 863–864
Syrjanen J, Valtonen VV, Iivanainen M, Hovi T, Malkamaki M, Makela PH (1986) Association between cerebral infarction and increased serum bacterial antibody levels in young adults. Acta Neurol Scand 73: 273–278
Syrjanen J, Valtonen VV, Iivanainen M, Kaste M, Huttunen JK (1988) Preceding infection as an important risk factor for ischaemic brain infarction in young and middle aged patients. Br Med J (Clin Res Ed) 296: 1156–1160
Macko RF, Ameriso SF, Barndt R, Clough W, Weiner JM, Fisher M (1996) Precipitants of brain infarction. Roles of preceding infection/inflammation and recent psychological stress [see comments]. Stroke: 27 1999–2004
Grau AJ, Buggle F, Heindl S, Steichen-Wiehn C, Banerjee T, Maiwald M, Rohlfs M, Suhr H, Fiehn W, Becher H et al (1995) Recent infection as a risk factor for cerebrovascular ischemia. Stroke 26: 373–379
Bova IY, Bornstein NM, Korczyn AD (1996) Acute infection as a risk factor for ischemic stroke. Stroke 27: 2204–2206
Woodhouse PR, Khaw KT, Plummer M, Foley A, Meade TW (1994) Seasonal variations of plasma fibrinogen and factor VII activity in the elderly: winter infections and death from cardiovascular disease. Lancet 343: 435–439
Syrjanen J, Peltola J, Valtonen V, Iivanainen M, Kaste M, Huttunen JK (1989) Dental infections in association with cerebral infarction in young and middle-aged men. J Intern Med 225: 179–184
Ameriso SF, Wong VL, Quismorio FP, Jr., Fisher M (1991) Immunohematologic characteristics of infection-associated cerebral infarction [see comments]. Stroke 22: 1004–1009
Melnick SL, Shahar E, Folsom AR, Grayston JT, Sorlie PD, Wang SP, Szklo M (1993) Past infection by Chlamydia pneumoniae strain TWAR and asymptomatic carotid atherosclerosis. Atherosclerosis Risk in Communities (ARIC) Study Investigators. Am J Med 95: 499–504
Wimmer ML, Sandmann-Strupp R, Saikku P, Haberl RL (1996) Association of chlamydial infection with cerebrovascular disease. Stroke 27: 2207–2210
Cook PJ, Honeybourne D, Lip GY, Beevers DG, Wise R, Davies P (1998) Chlamydia pneumoniae antibody titers are significantly associated with acute stroke and transient cerebral ischemia: the West Birmingham Stroke Project. Stroke 29: 404–410
Fagerberg B, Gnarpe J, Gnarpe H, Agewall S, Wikstrand J (1999) Chlamydia pneumoniae but not cytomegalovirus antibodies are associated with future risk of stroke and cardiovascular disease: a prospective study in middle-aged to elderly men with treated hypertension. Stroke 30: 299–305
Elkind MS, Lin IF, Grayston JT, Sacco RL (2000) Chlamydia pneumoniae and the risk of first ischemic stroke: The Northern Manhattan Stroke Study. Stroke 31: 1521–1525
Ross R (1999) Atherosclerosis is an inflammatory disease. Am Heart J 138: S419–S420
Wallberg-Jonsson S, Dahlen G, Johnson O, Olivecrona G, Rantapaa-Dahlqvist S (1996) Lipoprotein lipase in relation to inflammatory activity in rheumatoid arthritis. J Intern Med 240: 373–380
Wallberg-Jonsson S, Johansson H, Ohman ML, Rantapaa-Dahlqvist S (1999) Extent of inflammation predicts cardiovascular disease and overall mortality in seropositive rheumatoid arthritis. A retrospective cohort study from disease onset. J Rheumatol 26: 2562–2571
Hallenbeck JM (1996) Inflammatory reactions at the blood-endothelial interface in acute stroke. Adv Neurol 71: 281–297
del Zoppo G, Ginis I, Hallenbeck JM, Iadecola C, Wang X, Feuerstein GZ (2000) Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia. Brain Pathol 10: 95–112
Couffinhal T, Duplaa C, Labat L, Lamaziere JM, Moreau C, Printseva O, Bonnet J (1993) Tumor necrosis factor-alpha stimulates ICAM-1 expression in human vascular smooth muscle cells. Arterioscler Thromb 13: 407–414
Fassbender K, Dempfle CE, Mielke O, Rossol S, Schneider S, Dollman M, Hennerici M (1997) Proinflammatory cytokines: indicators of infection in high-risk patients. J Lab Clin Med 130: 535–539
Dechend R, Maass M, Gieffers J, Dietz R, Scheidereit C, Leutz A, Gulba DC (1999) Chlamydia pneumoniae infection of vascular smooth muscle and endothelial cells activates NF-kappaB and induces tissue factor and PAI-1 expression: a potential link to accelerated arteriosclerosis. Circulation 100: 1369–1373
Macko RF, Ameriso SF, Gruber A, Griffin JH, Fernandez JA, Barndt R, Quismorio FP, Jr, Weiner JM, Fisher M (1996) Impairments of the protein C system and fibrinolysis in infection-associated stroke. Stroke 27: 2005–2011
Hallenbeck JM, Dutka AJ, Kochanek PM, Siren A, Pezeshkpour GH, Feuerstein G (1988) Stroke risk factors prepare rat brainstem tissues for modified local Shwartzman reaction. Stroke 19: 863–869
Siren AL, Heldman E, Doron D, Lysko PG, Yue TL, Liu Y, Feuerstein G, Hallenbeck JM (1992) Release of proinflammatory and prothrombotic mediators in the brain and peripheral circulation in spontaneously hypertensive and normotensive Wistar-Kyoto rats. Stroke 23: 1643–1650; discussion 1650–1651
Siren AL, Liu Y, Feuerstein G, Hallenbeck JM (1993) Increased release of tumor necrosis factor-alpha into the cerebrospinal fluid and peripheral circulation of aged rats. Stroke 24: 880–886; discussion 887–888
Schmid-Schonbein GW, Seiffge D, DeLano FA, Shen K, Zweifach BW (1991) Leukocyte counts and activation in spontaneously hypertensive and normotensive rats [see comments]. Hypertension 17: 323–330
Schroder S, Palinski W, Schmid-Schonbein GW (1991) Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy. Am J Pathol 139: 81–100
Veniant M, Clozel JP, Kuhn H, Clozel M (1992) Protective effect of cilazapril on the cerebral circulation. J Cardiovasc Pharmacol 19: S94–S99
Duplaa C, Couffinhal T, Labat L, Fawaz J, Moreau C, Bietz I, Bonnet J (1993) Monocyte adherence to endothelial cells in patients with atherosclerosis: relationships with risk factors. Eur J Clin Invest 23: 474–479
Liu Y, Liu T, McCarron RM, Spatz M, Feuerstein G, Hallenbeck JM, Siren AL (1996) Evidence for activation of endothelium and monocytes in hypertensive rats. Am J Physiol 270: H2125–H2131
McCarron RM, Wang L, Siren AL, Spatz M, Hallenbeck JM (1994) Monocyte adhesion to cerebromicrovascular endothelial cells derived from hypertensive and normotensive rats. Am J Physiol 267: H2491–H2497
McCarron RM, Doron DA, Siren AL, Feuerstein G, Heldman E, Pollard HB, Spatz M, Hallenbeck JM (1994) Agonist-stimulated release of von Willebrand factor and procoagulant factor VIII in rats with and without risk factors for stroke. Brain Res 647: 265–272
McCarron RM, Wang L, Siren AL, Spatz M, Hallenbeck JM (1994) Adhesion molecules on normotensive and hypertensive rat brain endothelial cells. Proc Soc Exp Biol Med 205: 257–262
Liu Y, Jacobowitz DM, Barone F, McCarron R, Spatz M, Feuerstein G, Hallenbeck JM, Siren AL (1994) Quantitation of perivascular monocytes and macrophages around cerebral blood vessels of hypertensive and aged rats. J Cereb Blood Flow Metab 14: 348–352
Siren A-L, McCarron RM, Wang L, Garcia-Pinto P, Ruetzler C, Hallenbeck JM (2001) Proinflammatory cytokine expression contributes to brain injury provoked by chronic monocyte activation. Mol Med 7: 219–229
Alexander RW (1998) Atherosclerosis as disease of redox-sensitive genes. Trans Am Clin Climatol Assoc 109: 129–145
Chobanian AV, Alexander RW (1996) Exacerbation of atherosclerosis by hypertension. Potential mechanisms and clinical implications [see comments]. Arch Intern Med 156: 1952–1956
Chappell DC, Varner SE, Nerem RM, Medford RM, Alexander RW (1998) Oscillatory shear stress stimulates adhesion molecule expression in cultured human endothelium. Circ Res 82: 532–539
DeGraba TJ, Siren AL, Penix L, McCarron RM, Hargraves R, Sood S, Pettigrew KD, Hallenbeck JM (1998) Increased endothelial expression of intercellular adhesion molecule-1 in symptomatic versus asymptomatic human carotid atherosclerotic plaque. Stroke 29: 1405–1410
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Sirén, AL. (2001). Inflammation as a risk factor for stroke: evidence from experimental models. In: Feuerstein, G.Z. (eds) Inflammation and Stroke. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8297-2_3
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DOI: https://doi.org/10.1007/978-3-0348-8297-2_3
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