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Biphasic activity of tumor necrosis factor in stroke and brain trauma: interaction with reactive oxygen species

  • Chapter
Inflammation and Stroke

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Traumatic brain injury, which is the leading cause of death in young adults and children, is associated with motor, mental and behavioral disabilities in many of its survivors [1]. To date, none of the drugs which had been successfully tested in animal models made a breakthrough in the treatment of head injured patients.

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References

  1. Waxweiler RJ, Thurman D, Sniezek J, Sosin D, O’Neil J (1995) Monitoring the impact of traumatic brain injury: a review and update. J Neurotrauma 12: 509–516

    Article  PubMed  CAS  Google Scholar 

  2. Rothwell NJ, Hopkins SJ (1995) Cytokines and the nervous system II: action and mechanisms of action. Trends Neurosci 18: 130–136

    Article  PubMed  CAS  Google Scholar 

  3. Merril JE, Benveniste EN (1996) Cytokines in inflammatory brain lesions: helpful and harmful. Trends Neurosci 19: 331–338

    Article  Google Scholar 

  4. Barger S (1998) Tumor necrosis factor, the good, the bad and the umbra. In: MP Mattson (ed): Neuroprotective signal transduction. Humana Press, Totowa, NJ, 163–183

    Google Scholar 

  5. Munoz-Fernandez M, Fresno M (1998) The role of tumor necrosis factor, interleukin-6, Interferon-y and inducible nitric oxide synthase in the development and pathology of the nervous system. Prog Neurobiol 56: 307–340

    Article  PubMed  CAS  Google Scholar 

  6. Barone FC, Feuerstein, GZ (1999) Inflammatory mediators and stroke: new opportunities for novel therapeutics. J Cereb Blood Flow Metab 19: 819–834

    Article  PubMed  CAS  Google Scholar 

  7. Morganti-Kossman MC, Lenzlinger PM, Hans V, Stahel P, Csuka E, Ammann E, Stocker R, Trentz O, Kossmann T (1997) Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue. Mol Psych 2: 133–136

    Article  CAS  Google Scholar 

  8. Gourin CG, Shackford SR (1997) Production of tumor necrosis factor-alpha and interleukin-1 beta by human cerebral microvascular endothelium after percussive trauma. J Trauma 42: 1101–1107

    Article  PubMed  CAS  Google Scholar 

  9. Feuerstein GZ, Wang X, Barone FC (1997) Inflammatory gene expression in cerebral ischemia and trauma. Potential new therapeutic targets. Ann NY Acad Sci 825: 179–193 (review)

    Article  PubMed  CAS  Google Scholar 

  10. Liu T, Clark RK, McDonnel PC, Toung PR, White RF, Barone FC, Feuerstein FZ (1994) Tumor necrosis factor-alpha expression in ischemic neurons. Stroke 25: 1481–1488

    Article  PubMed  CAS  Google Scholar 

  11. Taupin V, Toulmond S, Serrano A, Benavides J, Zavala F (1993) Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion. Influence of pre-and post-traumatic treatment with Ro5 4864, a peripheral-type (p site) benzodiazepine ligand. J Neuroimmunol 42: 177–185

    Article  PubMed  CAS  Google Scholar 

  12. Shohami E, Gallily R, Mechoulam R, Bass, Ben-Hur T (1997) Cytokine production in the brain following closed head injury: Dexanabinol (HU-211) is a novel TNFa inhibitor and an effective neuroprotectant. J Neuroimmunol 72: 169–177

    Article  PubMed  CAS  Google Scholar 

  13. Shohami E, Novikov M, Bass R, Yamin A, Gallily R (1994) Closed head injury triggers early production of TNF and IL-6 by brain tissue. J Cereb Blood Flow Metabol 14: 615–619

    Article  CAS  Google Scholar 

  14. Fan L, Young PR, Barone FC, Feuerstein GZ, Smith DH, McIntosh TK (1996) Experimental brain injury induces differential expression of tumor necrosis factor-a mRNA in the CNS. Mol Br Res 36: 287–291

    Article  CAS  Google Scholar 

  15. Kita T, Liu L, Tanaka N, Kinoshita Y (1997) The expression of tumor necrosis factor-alpha in the rat brain after fluid percussive injury. Int J Legal Med 110: 305–311

    Article  PubMed  CAS  Google Scholar 

  16. Kaltschmidt B, Sparna T, Kaltschmidt C (1999) Activation of NF-KB by reactive oxygen intermediates in nervous system. Antiox Redox Signal 1: 129–144

    Article  CAS  Google Scholar 

  17. Grimaldi LM, Martino GV, Franciotta DM, Brustia R, Castagna A, Pristera R, Prizzarin A (1991) Elevated tumor necrosis factor-alpha levels in spinal fluid from HIV-1 infected patients with central nervous system involvement. Ann Neurol 29: 21–25

    Article  PubMed  CAS  Google Scholar 

  18. Leist TP, Frei K, Kam-Hansen S, Zinkernagel RM, Fontana A (1988) Tumor necrosis factor a in cerebrospinal fluid during bacterial, but not viral, meningitis: evaluation in murine model infections and in patients. J Exp Med 167: 1743–1758

    Article  PubMed  CAS  Google Scholar 

  19. Tracey KJ (1991) Tumor necrosis factor (cachectin) in the biology of septic shock syndrome. Circ Shock 35: 123–128

    PubMed  CAS  Google Scholar 

  20. Jiang J, Tian K, Chen H, Zhu P, Wang Z (1997) Kinetics of plasma cytokines and its clinical significance in patients with severe trauma. Chin Med J 110: 923–926

    PubMed  CAS  Google Scholar 

  21. Goodman JC, Robertson CS, Grossman RG, Narayan RK (1990) Elevation of tumor necrosis factor in head injury. J Neuroimmunol 30: 213–217

    Article  PubMed  CAS  Google Scholar 

  22. Ross SA, Halliday MI, Campbell GC, Byrnes DP, Rowlands BJ (1994) The presence of tumor necrosis factor in CSF and plasma after severe head injury. Br J Neurosurg 8: 419–425

    Article  PubMed  CAS  Google Scholar 

  23. Mathiesen T, Edner G, Ulfarsson E, Andersson B (1997) Cerebrospinal fluid interleukin1 receptor antagonist and tumor necrosis factor-alpha following subarachnoid hemorrhage. J Neurosurg 87: 215–220

    Article  PubMed  CAS  Google Scholar 

  24. Buttini M, Mir A, Appel K, Wiederhold KH, Limonta S, Gebicke-Haerter PJ, Boddeke HW (1997) Lipopolysaccharide induces expression of tumor necrosis factor alpha in rat brain: inhibition by methylprednisolone and by rolipram. Br J Pharmacol 122: 1483–1489

    Article  PubMed  CAS  Google Scholar 

  25. Novogrodsky A, Vanichkin A, Patya M, Gazit A, Osherov N, Levitzki A (1994) Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. Science 264: 1319–1322

    Article  PubMed  CAS  Google Scholar 

  26. Bianchi M, Bloom O, Raabe T, Cohen PS, Chesney J, Sherry B, Schmidtmayerova H, Calandra T, Zhang X, Bukrinsky M et al (1996) Suppression of proinflammatory cytokines in monocytes by a tetravalent guanylhydrazone. J Exp Med 183: 927–936

    Article  PubMed  CAS  Google Scholar 

  27. Meistrell ME 3rd, Botchkina GI, Wang H, Di Santo E, Cockroft KM, Bloom O, Vishnubhakat JM, Ghezzi P, Tracey K (1997) Tumor necrosis factor is a brain damaging cytokine in cerebral ischemia. Shock 8: 341–348

    Article  PubMed  Google Scholar 

  28. Nawashiro H, Martin D, Hallenbeck JM (1997) Inhibition of tumor necrosis factor ameliorated brain infarction in mice. J Cereb Blood Flow Metab 17: 229–232

    Article  PubMed  CAS  Google Scholar 

  29. Shohami E, Bass R, Wallach D, Yamin A, Gallily R (1996) Inhibition of tumor necrosis factor (TNFa) activity in rat brain is associated with cerebroprotection after closed head injury. J Cerebr Blood Flow Metab 16: 378–384

    CAS  Google Scholar 

  30. Leker R, Shohami E, Abramsky O, Ovadia H. (1999) Dexanabinol; a novel neuroprotective drug in experimental focal cerebral ischemia. J Neurol Sci 162: 114–119

    Article  PubMed  CAS  Google Scholar 

  31. Lavie G, Teichner A, Shohami E, Ovadia H, Leker RR (2001) Long term cerebropro-tective effects of dexanabinol in a model of focal cerebral ischemia. Brain Res 901: 195–201

    Article  PubMed  CAS  Google Scholar 

  32. Knoblach SM, Faden AI (1998) Interleukin-10 improves outcome and alters proinflammatory cytokine expression after experimental traumatic brain injury. Exp Neurol 153: 143–151

    Article  PubMed  CAS  Google Scholar 

  33. Bethea JR, Nagashima H, Acosta MC, Briceno C, Gomez F, Marcillo AE, Loor K, Green J, Dietrich WD (1999) Systemically administered Interleukin-10 rescues tumor necrosis factor-alpha production and significantly improves functional recovery following traumatic spinal cord injury in rats. J Neurotrauma 16: 851–863

    Article  PubMed  CAS  Google Scholar 

  34. Bruce AJ, Boling W, Kindy MS, Peschon J, Kraemer PJ, Carpenter MK, Holtsberg FW, Mattson MP (1996) Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nature Med 2: 788–794

    Article  PubMed  CAS  Google Scholar 

  35. Sullivan PG, Bruce-Keller AJ, Rabchevsky AG, Christakos S, Clair DK, Mattson MP, Scheff SW (1999) Exacerbation of damage and altered NF-kappaB activation in mice lacking tumor necrosis factor receptors after traumatic brain injury. J Neurosci 19: 6248–6256

    PubMed  CAS  Google Scholar 

  36. Stahel PF, Shohami E, Younis FM, Kariya K, Otto VI, Lenzlinger PM, Grosjean MB, Eugster HP, Trentz O, Kossmann T et al (2000) Experimental closed head injury: Analysis of neurological outcome, blood brain barrier dysfunction, intracranial neutrophil infiltration and neuronal cell death in mice deficient in genes for pro-inflammatory cytokines. J Cereb Blood Flood Metabol 20: 369–380

    Article  CAS  Google Scholar 

  37. Stahel PF, Kariya K, Shohami E, Barnum SR, Eugster H, Trentz O, Kossmann T, Morganti-Kossmann MC (2000) Intracerebral complement C5a receptor (CD88) expression is regulated by TNF and lymphtoxin-a following closed head injury in mice. J Neuroimmunol 109:164–172

    Article  PubMed  CAS  Google Scholar 

  38. Osaka H, Mukherjee P, Aisen P, Pasinetti GM, (1999) Complement-derived anaphylatoxin C5a protects against glutamate-mediated neurotoxicity. J Cell Biochem 73: 303–311

    Article  PubMed  CAS  Google Scholar 

  39. Scherbel U, Raghupathi R, Nakamura M, Saatman KE, Trojanowski JQ, Neugebauer E, Marino MW, McIntosh TK (1999) Differential acute and chronic responses of tumor necrosis factor-deficient mice to experimental brain injury. Proc Natl Acad Sci USA 96: 8721–8726

    Article  PubMed  CAS  Google Scholar 

  40. Galasso JM, Wang P, Martin D, Silverstein FS (2000) Inhibition of TNFa can attenuate or exacerbate excitotoxic injury in neonatal rat barin. NeuroReport 11: 231–235

    Article  PubMed  CAS  Google Scholar 

  41. Phillips LM, Simon PJ, Lampson LA (1999) Site-specific immune regulation in the brain: differential modulation of major histocompatibility complex (MHC) proteins in brain-stem vs. hippocampus. J Comp Neurol 405: 322–333

    Article  PubMed  CAS  Google Scholar 

  42. Barger SW, Horster D, Furukawa K, Goodman Y, Krieglstein J, Mattson MP (1995) Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation. Proc Nat Acad Sci USA 92: 9328–9332

    Article  PubMed  CAS  Google Scholar 

  43. Mattson MP, Cheng B, Baldwin SA, Smith-Swintosky VL, Keller J, Geddes JW, Scheff SW, Christakos S. (1995) Brain injury and tumor necrosis factors induce calbindin D-28k in astrocytes: evidence for a cytoprotective response. J Neur Res 42: 357–370

    Article  CAS  Google Scholar 

  44. Chan PH, (1996) Role of oxidants in ischemic brain damage. Stroke 27: 1124–1129

    Article  PubMed  CAS  Google Scholar 

  45. Beit-Yannai E, Zhang R, Trembovler V, Samuni A, Shohami E (1996) Cerebroprotective effect of stable nitroxide radicals in closed head injury in the rat. Brain Res 717: 22–28

    Article  PubMed  CAS  Google Scholar 

  46. Beit-Yannai E, Kohen R, Horowitz M, Trembovler V, Shohami E (1997) Changes in biological reducing activity in rat brain following closed head injury: a cyclic voltammetry study in normal and acclimated rats. J Cereb Blood Flow Metabol 17: 273–279

    CAS  Google Scholar 

  47. Trembovler V, Beit-Yannai E, Younis F, Gallily R, Horowitz M, Shohami E (1999) Antioxidants attenuate acute toxicity of tumor necrosis factor a induced by brain injury in Rat. J Interferon Cytokine Res 19: 791–795

    Article  PubMed  CAS  Google Scholar 

  48. Ginis I, Hallenbeck JM, Liu J, Spatz M, Jaiswal R, Shohami E (2000) Tumor necrosis factor and reactive oxygen species cooperative cytotoxicity is mediated via inhibition of NF-KB. Mol Med 6: 1028–1041

    PubMed  CAS  Google Scholar 

  49. Trembovler V, Abu-Raya S, Lazarovic P, Shohami E (2000) Toxic effects of tumor necrosis factor alpha are enhanced by reactive oxygen species. 5th Intl. Neurotrauma symposium, Garmisch, Germany (abstract)

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pharmacology, The Hebrew University School of Pharmacy, Jerusalem, 91120, Israel

    Esther Shohami

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  1. Esther Shohami
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Editors and Affiliations

  1. Cardiovascular Diseases Research Experimental Station, DuPont Pharmaceuticals Company, Route 141 & Henry Clay Road, Wilmington, DE, 19880, USA

    Giora Z. Feuerstein

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© 2001 Springer Basel AG

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Shohami, E. (2001). Biphasic activity of tumor necrosis factor in stroke and brain trauma: interaction with reactive oxygen species. In: Feuerstein, G.Z. (eds) Inflammation and Stroke. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8297-2_13

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  • DOI: https://doi.org/10.1007/978-3-0348-8297-2_13

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9508-8

  • Online ISBN: 978-3-0348-8297-2

  • eBook Packages: Springer Book Archive

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