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Direct and indirect modulation of the inducible nitric oxide synthase by nitric oxide: feedback mechanisms in inflammation

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Nitric Oxide and Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Cytokines are peptide hormones with a vast array of effects on growth, development, immunity, and disease that are regulated in complex ways at the transcriptional, post-transcriptional, translational, and post-translational levels. Cytokine activities interact with one another, regulate each other’s expression and activity, and baffle investigators with their often-overlapping spectra of action [1]. Cytokines are required to mediate many cellular functions and thereby affect physiology and pathology. One target of many cytokines is regulation of reactive oxygen species (ROS) and reactive nitrogen oxide species (RNOS). In turn, ROS such as Superoxide and RNOS such as nitric oxide (NO) and its reaction products can modulate the expression and function of numerous cytokines. Nitric oxide is of particular biological interest because its rapid and wide-ranging effects on physiological responses pose a central problem to determine how the system is ramped up quickly, and furthermore, due to its toxicity, what controls are in place to modulate its activity.

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Authors and Affiliations

  1. Department of Surgery, UPMC Montefiore, University of Pittsburgh, NW 653, 3459 Fifth Avenue, Pittsburgh, PA, 15213, USA

    Yoram Vodovotz

  2. Life Sciences Division, Lawrence Berkeley Laboratory, Berkeley, CA, 94720, USA

    Mary H. Barccellos-Hoff

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  1. Yoram Vodovotz
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  2. Mary H. Barccellos-Hoff
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Editors and Affiliations

  1. MetaPhore Pharmaceuticals, 3655 Vista Avenue, St. Louis, MO, 63110, USA

    Daniela Salvemini Ph.D.

  2. Department of Surgery, A1010 Presbyterian University Hospital, 200 Lothrop Street, Pittsburgh, PA, 15213, USA

    Timothy R. Billiar M.D.

  3. Department of Surgery, UPMC Montefiore, University of Pittsburgh, NW 653 3459 Fifth Avenue, Pittsburgh, PA, 15213, USA

    Yoram Vodovotz Ph.D.

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© 2001 Springer Basel AG

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Vodovotz, Y., Barccellos-Hoff, M.H. (2001). Direct and indirect modulation of the inducible nitric oxide synthase by nitric oxide: feedback mechanisms in inflammation. In: Salvemini, D., Billiar, T.R., Vodovotz, Y. (eds) Nitric Oxide and Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8241-5_3

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  • DOI: https://doi.org/10.1007/978-3-0348-8241-5_3

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9488-3

  • Online ISBN: 978-3-0348-8241-5

  • eBook Packages: Springer Book Archive

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