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Nitric Oxide and Inflammation pp 207–223Cite as

Birkhäuser

Nitric oxide and myocarditis

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Myocarditis is an inflammatory disease of the heart, usually caused by viral infection. The clinical course of patients with myocarditis is paradoxical. The survival of patients with mild forms of myocarditis is much worse than the survival of patients with severe, fulminant myocarditis. One hypothesis explaining this paradox involves nitric oxide (NO). Perhaps myocarditic patients who produce large amounts of NO clear their viral infections and so survive longer, although they suffer from hemodynamic instability due to excess NO. Conversely, myocarditic patients who generate less NO are hemodynamically stable, but less NO permits greater levels of viral replication, leading to a higher mortality. This review examines the role of NO in myocarditis, focusing on viral myocarditis.

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Authors and Affiliations

  1. Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, 720 Rutland Ave., Baltimore, MD, 21205, USA

    Charles J. Lowenstein & Tomokazu Ohnishi

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  1. Charles J. Lowenstein
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  2. Tomokazu Ohnishi
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Editors and Affiliations

  1. MetaPhore Pharmaceuticals, 3655 Vista Avenue, St. Louis, MO, 63110, USA

    Daniela Salvemini Ph.D.

  2. Department of Surgery, A1010 Presbyterian University Hospital, 200 Lothrop Street, Pittsburgh, PA, 15213, USA

    Timothy R. Billiar M.D.

  3. Department of Surgery, UPMC Montefiore, University of Pittsburgh, NW 653 3459 Fifth Avenue, Pittsburgh, PA, 15213, USA

    Yoram Vodovotz Ph.D.

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© 2001 Springer Basel AG

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Lowenstein, C.J., Ohnishi, T. (2001). Nitric oxide and myocarditis. In: Salvemini, D., Billiar, T.R., Vodovotz, Y. (eds) Nitric Oxide and Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8241-5_13

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  • DOI: https://doi.org/10.1007/978-3-0348-8241-5_13

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9488-3

  • Online ISBN: 978-3-0348-8241-5

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