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Inflammation in coronary atherosclerosis - pathological aspects

  • Chapter
Inflammatory and Infectious Basis of Atherosclerosis

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Inflammation is an important mechanism in the initiation and progression of a developing atherosclerotic plaque [1-3]. The first cell to adhere to the intact endothelium is the circulating monocyte, which eventually migrates between endothelial cells, locates itself in the subendothelial space, and transforms into the foamy macrophage through the ingestion of lipids. The recruitment of macrophages within the intima is governed by a myriad of adhesion molecules, chemotactic agents, growth factors, and cytokines, all critical to the induction of atherosclerosis. The processes by which lipids accumulate and recruit inflammatory cells to sites of predilection for coronary atherosclerosis are under intense investigation. In addition, the possibility of infectious agents as initiators of coronary inflammation is also currently being explored [1]. The purpose of this review is to focus on the pathological aspects of inflammation in the coronary atherosclerotic plaque. Because the role of inflammation varies as a function of the stage and type of atherosclerotic plaque, the inflammatory milieu will be considered in context of plaque progression; early intimai thickening to complex symptomatic lesions that may be fatal. Plaques will be classified according the terminology of our recent review [4]; conventional definitions provided by the American Heart Association (AHA) classification [5,6] will also be stated.

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Authors and Affiliations

  1. Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, 6825 16th Street N.W., Washington, DC, 20306-600, USA

    Renu Virmani, Frank D. Kolodgie, Allen P. Burke & Andrew Farb

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  1. Renu Virmani
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  2. Frank D. Kolodgie
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  3. Allen P. Burke
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  4. Andrew Farb
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  1. Division of Cardiovascular Disease, University of Arkansas for Medical Sciences, 4301 West Markham, Mail Slot 532, Little Rock, AR, 72205-7199, USA

    Jay L. Mehta

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Virmani, R., Kolodgie, F.D., Burke, A.P., Farb, A. (2001). Inflammation in coronary atherosclerosis - pathological aspects. In: Mehta, J.L. (eds) Inflammatory and Infectious Basis of Atherosclerosis. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8239-2_2

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  • DOI: https://doi.org/10.1007/978-3-0348-8239-2_2

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