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Inflammation as a Marker of Outcome in Myocardial Ischemia

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Book cover Inflammatory and Infectious Basis of Atherosclerosis

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Ischemic heart disease (IHD) is a major health problem, and accounts for almost 50% of all deaths and for a large part of hospitalization and health system costs [1,2]. IHD is also a devastating problem for the individuals affected by this disease. One of the problems related to IHD is the relative lack of reliable and affordable methods for risk stratification. IHD represents a clinical spectrum ranging from sudden death to mild stable angina. Clinical data are sufficient to judge that the outcome of patients with a large anterior myocardial infarction (MI), a very low ejection fraction (EF) and in New York Heart Association (NYHA) class III or IV is very different from that of patients with angina in NYHA class 1 and no coronary risk factors. However, it is often difficult to predict the prognosis of patients with IHD. The clinical data, and the non-invasive and invasive diagnostic tests are of little help in many patients. Traditional risk factors can explain only one half of all causes of MI. Further, the majority of MIs develop in the presence of non-significant coronary stenoses. Recently, growing evidence indicates that markers of inflammation may provide a more accurate prognostic stratification of IHD patients [3-5].

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Authors and Affiliations

  1. Institute of Cardiology, Catholic University, 00168, Largo Vito, Italy

    Luigi M. Biasucci, Dominick J. Angiolillo & Giovanna Liuzzo

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  1. Luigi M. Biasucci
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  2. Dominick J. Angiolillo
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  3. Giovanna Liuzzo
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Editors and Affiliations

  1. Division of Cardiovascular Disease, University of Arkansas for Medical Sciences, 4301 West Markham, Mail Slot 532, Little Rock, AR, 72205-7199, USA

    Jay L. Mehta

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Biasucci, L.M., Angiolillo, D.J., Liuzzo, G. (2001). Inflammation as a Marker of Outcome in Myocardial Ischemia. In: Mehta, J.L. (eds) Inflammatory and Infectious Basis of Atherosclerosis. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8239-2_14

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  • DOI: https://doi.org/10.1007/978-3-0348-8239-2_14

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9487-6

  • Online ISBN: 978-3-0348-8239-2

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