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Behavioural studies on the potential of NMDA receptor antagonists as analgesics

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NMDA Antagonists as Potential Analgesic Drugs

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Neuropathic pain in man may result from various insults to peripheral and central nerves, including mechanical compression (for example by tumours), treatment with cytotoxic chemotherapeutic drugs, traumatic injury (such as limb amputation), herpes zoster infection and diabetes. These conditions are often poorly controlled by opioid analgesics [1] or non-steroidal anti-inflammatory drugs [2]. Recent attention has, therefore, focused on N-methyl-D-aspartate (NMDA) receptor antagonists for the treatment of neuropathic pain and other pain states. The non-competitive NMDA antagonists (ion channel blockers), ketamine [3-7] and dextromethorphan [8], and the competitive antagonist, CPP (3-(2-carboxypiperazin-4-yl)-propyl-1phosphonic acid) [9] gave symptomatic relief from a range of painful neuropathies in man (postherpetic neuralgia, diabetic neuropathy, peripheral nerve injury, central pain, phantom limb pain). In addition, ketamine is also effective in relieving postoperative orofacial pain caused by third molar tooth extraction [10], suggesting that NMDA antagonists are also analgesic against inflammatory pain in man.

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Boyce, S.G., Rupniak, N.M.J. (2002). Behavioural studies on the potential of NMDA receptor antagonists as analgesics. In: Sirinathsinghji, D.J.S., Hill, R.G. (eds) NMDA Antagonists as Potential Analgesic Drugs. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8139-5_8

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