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Some pharmacological aspects of NMDA-mediated nociceptive transmission in the rat spinal cord as revealed by c-Fos immunocytochemistry

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Book cover NMDA Antagonists as Potential Analgesic Drugs

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

An important facet of the somatosensory system is the ability to distinguish a broad array of stimuli, resulting in the perception of a wide range of sensations. Under normal conditions this system can differentiate between innocuous (Aβ-fibre mediated) and noxious (C-fibre mediated) stimuli, with thresholds and responses being well defined. Following a sustained peripheral injury, persistent peripheral inputs from the injury site (tissue or nerve) can lead to plasticity of the somatosensory system. Under these conditions responses/sensations evoked by different types of peripheral stimuli may be altered. Inflammation of the tissue results in a peripheral sensitisation; nociceptors at the injury site exhibit spontaneous activity, lowered thresholds and enhanced responses to suprathreshold stimuli (hyperalgesia) (see references in [1]). A consequence of these peripheral events is a sustained neuronal input from the periphery to the spinal cord that may in due course initiate events leading to the establishment of central sensitisation.

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Authors and Affiliations

  1. INSERM U 161 and EPHE, 2 Rue d’Alésia, 75014, Paris, France

    Stéphanie Le Guen & Jean-Marie Besson

  2. School of Biomedical Sciences, E Floor, Medical School, Queen’s Medical Centre, Nottingham, NG7 2UH, UK

    Victoria Chapman

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  1. Merck, Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Harlow, Essex, CM20 2QR, UK

    Dalip J. S. Sirinathsinghji  & Ray G. Hill  & 

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Le Guen, S., Chapman, V., Besson, JM. (2002). Some pharmacological aspects of NMDA-mediated nociceptive transmission in the rat spinal cord as revealed by c-Fos immunocytochemistry. In: Sirinathsinghji, D.J.S., Hill, R.G. (eds) NMDA Antagonists as Potential Analgesic Drugs. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8139-5_6

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