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Spinal nociceptive processing: NMDA receptors and modulation by neuropeptides

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NMDA Antagonists as Potential Analgesic Drugs

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

The excitatory amino acids, glutamate and aspartate, have long been recognised as being fundamental to the processing of nociceptive and non-nociceptive information in the spinal cord (for review see [1]). Both of these neurotransmitters are released into the dorsal horn following noxious peripheral stimulation [2]. In the early 1960s it was found that glutamate and aspartate strongly excited spinal neurones [3] and that various analogues of these amino acids were also potently active. Amongst these was NMDA [4]. It was proposed that, based upon the differential potencies of various excitant amino acids on different types of spinal neurones, a specific NMDA sensitive site existed [5, 6]. It was also found that Mg2+ could selectively inhibit responses to NMDA in the spinal cord [7] which has led to the current understanding of the voltage dependent Mg2+ block of the NMDA receptor [8]. Since these early experiments the NMDA receptor has been extensively characterised and molecular cloning techniques have revealed a variety of subunits that have a differential distribution throughout the central nervous system.

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Authors and Affiliations

  1. Merck, Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Harlow, Essex, CM20 2QR, UK

    Michael J. Cumberbatch

  2. Grünenthal GmbH, Research and Development, Zieglerstrasse 6, Aachen, D-52078, Germany

    Boris A. Chizh

  3. Department of Physiology, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK

    P. Max Headley

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  1. Michael J. Cumberbatch
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  1. Merck, Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Harlow, Essex, CM20 2QR, UK

    Dalip J. S. Sirinathsinghji  & Ray G. Hill  & 

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Cumberbatch, M.J., Chizh, B.A., Headley, P.M. (2002). Spinal nociceptive processing: NMDA receptors and modulation by neuropeptides. In: Sirinathsinghji, D.J.S., Hill, R.G. (eds) NMDA Antagonists as Potential Analgesic Drugs. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8139-5_4

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