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Genetic regulation of specific IgE responsiveness

  • Chapter
The Hereditary Basis of Allergic Diseases

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Allergic reactions are the result of specific immunoglobulin E (IgE) antibody production in response to common innocuous antigens. Atopic people are intrinsically prone to produce IgE antibodies against many different allergens. IgE antibody production is driven by antigen-specific Th2 cells that secrete a distinct repertoire of cytokines, including IL-4, IL-5, IL-6, IL-9, and IL-13. Specific IgE responsiveness toward house dust mite (HDM) is associated with asthma and bronchial hyperresponsiveness [1-3]. Specific IgE responses toward allergens derived from cats, dogs, cockroaches, and pollens also contribute significantly to the development of allergic diseases. In particular, a clear correlation was recently demonstrated among cockroach allergy, level of exposure to cockroaches, and asthma-related health problems in inner-city children [4]. Because of the impact that allergies have on public health, it is critical to identify susceptibility factors in the development of specific IgE responses toward common environmental allergens.

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  1. First Department of Medicine, School of Medicine, Hokkaido University, Kita-Ku, N-15 W-7, Sapporo, 060-8638, Japan

    Nobuyuki Hizawa

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  1. School of Medicine IIR (Respiratory Cell and Molecular Biology) Division Southampton General Hospital, University of Southampton, Southampton, SO16 6YD, UK

    Stephen T. Holgate

  2. School of Medicine Human Genetics and IIR (Respiratory Cell and Molecular Biology) Divisions, University of Southampton, Southampton, SO16 6YD, UK

    John W. Holloway

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Hizawa, N. (2002). Genetic regulation of specific IgE responsiveness. In: Holgate, S.T., Holloway, J.W. (eds) The Hereditary Basis of Allergic Diseases. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8137-1_4

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  • DOI: https://doi.org/10.1007/978-3-0348-8137-1_4

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