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The role of founder populations in mapping complex disease genes: Studies in the South Dakota Hutterites

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The Hereditary Basis of Allergic Diseases

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Founder populations are populations that are derived from a well-defined ancestral population with little admixture since their founding. Founder populations can be old and derived from a larger number of ancestors, such as the Finnish, Icelandic, Ashkenazi, and Sardinian populations, or young and derived from a much smaller number of founders, such as the Amish, Hutterites, and Tristan de Cunhans [1]. The latter group of founder populations is also inbred, i.e., the inbreeding coefficient is > 0 for nearly everyone in the population because all matings are consanguineous.

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Author information

Authors and Affiliations

  1. Department of Human Genetics, The University of Chicago, 920 East 58th Street, Room 507C, Chicago, IL, 60627, USA

    Carole Ober

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  1. Carole Ober
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Editors and Affiliations

  1. School of Medicine IIR (Respiratory Cell and Molecular Biology) Division Southampton General Hospital, University of Southampton, Southampton, SO16 6YD, UK

    Stephen T. Holgate

  2. School of Medicine Human Genetics and IIR (Respiratory Cell and Molecular Biology) Divisions, University of Southampton, Southampton, SO16 6YD, UK

    John W. Holloway

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© 2002 Springer Basel AG

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Ober, C. (2002). The role of founder populations in mapping complex disease genes: Studies in the South Dakota Hutterites. In: Holgate, S.T., Holloway, J.W. (eds) The Hereditary Basis of Allergic Diseases. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8137-1_3

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  • DOI: https://doi.org/10.1007/978-3-0348-8137-1_3

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9452-4

  • Online ISBN: 978-3-0348-8137-1

  • eBook Packages: Springer Book Archive

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