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Genetic regulation of leukotriene production and activity

  • Chapter
The Hereditary Basis of Allergic Diseases

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Leukotrienes (LTs) have been identified as critical mediators of airway narrowing and eosinophilia in bronchial asthma. They potently contract human bronchial smooth muscle, promote mucus secretion and impair muciliary clearance, increase vascular permeability leading to airway oedema, and, specifically, chemoattract human eosinophils in vitro and in vivo. In view of the importance of these lipid mediators in the pathogenesis of asthma, substantial effort has been directed at elucidating the mechanisms that regulate their production by the 5-lipoxygenase pathway and those that mediate their effects [1]. This work led directly to the development of a series of LT modifier drugs that show clinical efficiency in asthma and represent the first new form of asthma treatment in 25 years [2, 3].

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Authors and Affiliations

  1. Human Genetics, Southampton General Hospital, Tremona Road, Southampton, S016 6YD, UK

    I. Sayers

  2. Respiratory Cell & Molecular Biology Research Division, Southampton General Hospital, Tremona Road, Southampton, S016 6YD, UK

    A. P. Sampson

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  1. School of Medicine IIR (Respiratory Cell and Molecular Biology) Division Southampton General Hospital, University of Southampton, Southampton, SO16 6YD, UK

    Stephen T. Holgate

  2. School of Medicine Human Genetics and IIR (Respiratory Cell and Molecular Biology) Divisions, University of Southampton, Southampton, SO16 6YD, UK

    John W. Holloway

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Sayers, I., Sampson, A.P. (2002). Genetic regulation of leukotriene production and activity. In: Holgate, S.T., Holloway, J.W. (eds) The Hereditary Basis of Allergic Diseases. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8137-1_10

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  • DOI: https://doi.org/10.1007/978-3-0348-8137-1_10

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  • Print ISBN: 978-3-0348-9452-4

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