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Osteogenic protein-1 and its receptors in human articular cartilage

  • Conference paper
The Many Faces of Osteoarthritis

Abstract

Cartilage regeneration and repair is one of the major obstacles to treat arthritic diseases. The members of the bone morphogenetic protein (BMP) family of the transforming growth factor-β (TGFβ) superfamily received a high degree of attention among factors potentially capable of inducing and promoting anabolic processes in articular cartilage [1, 2]. BMPs were first isolated from demineralized bone matrix and shown to induce ectopic bone formation when implanted subcutaneously [3, 4]. The BMP family currently consists of more than 47 related molecules identified in different species [5,6]. Although BMPs were initially found in bone matrix, it has been shown that they are present in most tissues and organs. They are involved in numerous physiological and pathological processes: differentiation, embryogenesis, morphogenesis, skeletal patterning, development, tissue regeneration, organogenesis, apoptosis, etc.

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Author information

Authors and Affiliations

  1. Departments of Biochemistry, Rush Medical College at Rush-Presbyterian-St, Luke’s Medical Center, 1653 W. Congress Parkway, Chicago, IL, 60612, USA

    Susan Chubinskaya & Klaus E. Kuettner

  2. Departments of Section of Rheumatology, Rush Medical College at Rush-Presbyterian-St, Luke’s Medical Center, 1653 W. Congress Parkway, Chicago, IL, 60612, USA

    Susan Chubinskaya

  3. Departments of Orthopedic Surgery, Rush Medical College at Rush-Presbyterian-St, Luke’s Medical Center, 1653 W. Congress Parkway, Chicago, IL, 60612, USA

    Richard A. Berger & Klaus E. Kuettner

  4. Stryker Biotech, Hopkinton, MA, 01748, USA

    David C. Rueger

Authors
  1. Susan Chubinskaya
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  2. David C. Rueger
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  3. Richard A. Berger
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  4. Klaus E. Kuettner
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Editor information

Editors and Affiliations

  1. Department of Biomedical Engineering, The Cleveland Clinic Foundation, Orthopaedic Research Center, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Vincent C. Hascall

  2. Department of Biochemistry, Rush Medical College at Rush Presbyterian-St. Luke’s Medical Center, 1653 West Congress Parkway, Chicago, IL, 60612-3864, USA

    Klaus E. Kuettner

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© 2002 Springer Basel AG

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Chubinskaya, S., Rueger, D.C., Berger, R.A., Kuettner, K.E. (2002). Osteogenic protein-1 and its receptors in human articular cartilage. In: Hascall, V.C., Kuettner, K.E. (eds) The Many Faces of Osteoarthritis. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8133-3_9

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  • DOI: https://doi.org/10.1007/978-3-0348-8133-3_9

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9450-0

  • Online ISBN: 978-3-0348-8133-3

  • eBook Packages: Springer Book Archive

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