Abstract
Osteoarthritis (OA) is characterized by the failure of anabolic processes to keep up with an acceleration in catabolic processes. The role that inflammation, trauma, instability and other factors play in the initiation and progression of OA are still poorly understood [1, 2]. A possible approach to slow down the degeneration of the articular surface might be to administer locally or systemically anabolic factors that promote matrix synthesis and repair [3]. Such factors include osteogenic proteins and bone morphogenic proteins (OPs/BMPs) that have been shown capable of inducing cartilage and bone formationin vivo[4,5].
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References
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© 2002 Springer Basel AG
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Koepp, H.E., Flechtenmacher, J., Huch, K., Thonar, E.J.M., Homandberg, G.A., Kuettner, K.E. (2002). Osteogenic protein-1 promotes proteoglycan synthesis and inhibits cartilage degeneration mediated by fibronectinfragments. In: Hascall, V.C., Kuettner, K.E. (eds) The Many Faces of Osteoarthritis. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8133-3_8
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DOI: https://doi.org/10.1007/978-3-0348-8133-3_8
Publisher Name: Birkhäuser, Basel
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