Abstract
Our studies of human articular cartilages began approximately 13 years ago when collaboration was established between the Department of Biochemistry of Rush Medical College and the Regional Organ Bank of Illinois. As of April 2001, this collaboration has resulted in the acquisition of cartilages from more than 1900 different donors, including about 250 donors from whom we received both knees and ankles and 1656 donors from whom we received only ankles. These are primarily adult donors with a mean age of 51.5 years, 90% men, 99% Caucasian; these gender and race are a reflection of the population of donors received by the Regional Organ Bank of Illinois. The knee (tibiofemoral) and ankle (talocrural) joints are graded on a five-point scale of Collins [1] as modified by Muehleman et al. [2] and reported by Koepp et al. [3]. Of the ankles that have been graded, 53% are macroscopically normal and have received a Collins grade of 0, while only the 483 knee joints (35%) received a Collins grade of 0, For the knee and ankle metabolic, biochemical and biomechanical comparisons, we have used joints from the same limb (matched pairs) from donors with grade 0 in the ankle and grades 0 and 1 in the knee.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Collins DH (1949) The pathology of articular and spinal diseases. London: Edward Arnold and Co., 76–79
Muehleman C, Barreither D, Huch K, Cole AA, Kuettner KE (1997) Prevalence of degenerative morphologic changes in the joints of the lower extremities. Osteoarthritis Cartilage 5: 23–37
Kocpp H, Eger W, Muehleman C, Valdellon A, Buckwalter JA, Kuettner KE, Cole AA (1999) Prevalence of articular cartilage degeneration in the ankle and knee joints of human organ donors. J Orthop Sci 4: 407–412
Treppo S, Koepp H, Quan EQ, Cole AA, Kuettner KE, Grodzinsky AJ (2000) Comparison of biomechanical and biochemical properties of cartilage from human knee and ankle pairs. J Orthop Res 18: 739–748
Egcr W, Schumacher BL, Margulis A, Aydelotte MD, Mollenhauer J, Kuettner KE, Cole AA (1999) Metabolic differences in the degradation progression between knee and ankle cartilage. Trans Ortho Res Soc 24: 446
Kang Y, Koepp H, Cole AA, Kuettner KE, Homandberg GA (1998) Cultured human ankle and knee cartilage differ in susceptibility to damage mediated by fibronectin fragments. J Orthop Res 16: 551–556
Häuselmann HJ, Mok SS, Flechtenmacher J, Gitelis SH, Kuettner KE (1993) Chondro-cytes from human knee and ankle joints show differences in response to IL-1 and IL-1 receptor inhibitor. Trans Ortho Res Soc 18: 280
Sumner DR, Koepp H, Berzins A, Eger W, Muehleman C, Cole A, Kuettner KE (1998) Bone density of the human talus does not vary as a function of the cartilage damage score. Trans Ortho Res Soc 23: 722
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer Basel AG
About this paper
Cite this paper
Cole, A. et al. (2002). Metabolic differences between knee and ankle. In: Hascall, V.C., Kuettner, K.E. (eds) The Many Faces of Osteoarthritis. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8133-3_3
Download citation
DOI: https://doi.org/10.1007/978-3-0348-8133-3_3
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-9450-0
Online ISBN: 978-3-0348-8133-3
eBook Packages: Springer Book Archive