Abstract
The tissues in the joint, i.e. cartilage and bone, continuously remodel in a finely tuned balance between matrix synthesis and degradation. In common diseases like osteoarthritis (OA) and rheumatoid arthritis (RA), the normal balance is disturbed and shifted towards degradation in established disease. This eventually leads to disruption of the structural and functional integrity of the joint. As a consequence of the disturbed matrix turnover, increased amounts of macromolecules or fragments thereof are released into synovial fluid and may subsequently reach the blood stream. Some fragments may also be found in the urine. This sequence of events forms the rationale for efforts to identify alterations in the tissue by quantifying matrix macromolecules, “molecular markers”, in body fluids with the purpose to define non-invasive methods to monitor pathological tissue processes [1].
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References
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Saxne, T., Heinegård, D., Månsson, B. (2002). Markers of joint tissue turnover in osteoarthritis. In: Hascall, V.C., Kuettner, K.E. (eds) The Many Faces of Osteoarthritis. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8133-3_28
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DOI: https://doi.org/10.1007/978-3-0348-8133-3_28
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