Skip to main content

Age-dependent changes in some physico-chemical properties of human articular cartilage

  • Conference paper
Book cover The Many Faces of Osteoarthritis

Abstract

It is well known that osteoarthritis (OA) is associated with advancing age. However, a large number of elderly people do not develop OA and a survey of aged cartilage, in the absence of degeneration, reveals unchanged physico-chemical characteristics. The object of this article is to describe some of the physical properties of femoral head and femoral condyle cartilage as a function of age and in OA. The properties with which we shall deal are the osmotic pressure of proteoglycan (PG) extracted from cartilage and the stiffness of the collagen network.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Stockwell RA (1970) Changes in the acid glycosaminoglycan content of the matrix of human cartilage. Ann Rheum Dis 29: 509–515

    Article  PubMed  CAS  Google Scholar 

  2. Hjertquist SO, Lemperg RC (1967) Identification and concentration of the glycosamino-glycans of human articular cartilage in relation to age and osteoarthritis. Calcified Tissue Research 10: 223–227

    Article  Google Scholar 

  3. Venn MF (1978) Variation of chemical composition with age in human femoral head cartilage. Ann Rheum Dis 37: 168–174

    Article  PubMed  CAS  Google Scholar 

  4. Bayliss MT (1986) Proteoglycan structure in normal and osteoarthrotic human cartilage . In: K Kuettner et al (eds): Articular cartilage biochemistry. Raven Press, New York, 295–310

    Google Scholar 

  5. Bayliss MT (1990) Extraction and purification of proteoglycan and hyaluronan from human articular cartilage. In: A Maroudas, K Kuettner (eds): Methods in cartilage research. Academic Press, London, 220–222

    Google Scholar 

  6. Maroudas A, Bayliss MT, Uchitel-Kaushansky N, Schneiderman R, Gilav E (1998) Aggrecan turnover in human articular cartilage: Use of aspartic acid racemization as a marker of molecular age. Arch Biochem Biophys 350(1): 61–71

    Article  PubMed  CAS  Google Scholar 

  7. Urban JPG, Maroudas A, Bayliss MT, Dillon J (1979) Swelling pressures of proteoglycans at the concentrations found in cartilaginous tissues. Biorheology 16: 447–464

    PubMed  CAS  Google Scholar 

  8. Maroudas A, Bayliss MT, Venn MF (1980) Further studies on the composition of human femoral head cartilage. Ann Rheum Dis 39: 514–523

    Article  PubMed  CAS  Google Scholar 

  9. Grushko G, Schneiderman R, Maroudas A (1989) Some biochemical and biophysical parameters for the study of the pathogenesis of osteoarthritis: A comparison between the processes of ageing and degeneration in human hip cartilage. Conn Tiss Res 19: 149–176

    Article  CAS  Google Scholar 

  10. Basser PJ, Schneiderman R, Bank RA, Wachtel E, Maroudas A (1998) Mechanical properties of the collagen network in human articular cartilage as measured by osmotic stress technique. Arch Biochem Biophys 351(2): 207–219

    Article  PubMed  CAS  Google Scholar 

  11. Bank RA, Bayliss MT, Lafeber FPJG, Maroudas A, Tekoppele JM (1998) Ageing and zonal variation in posttranslational modification of collagen in normal human articular cartilage. Biochem J 330: 345–351

    PubMed  CAS  Google Scholar 

  12. Mizrahi J, Maroudas A, Lanir Y, Ziv I, Weber TJ (1986) The (instantaneous) deformation of cartilage: Effects of collagen fiber orientation and osmotic stress. Biorheology 23: 311–330

    PubMed  CAS  Google Scholar 

  13. Bank RA, Soudry M, Maroudas A, Mizrahi J, TeKoppele JM (2000) The increased swelling and instantaneous deformation of osteoarthritic cartilage is highly correlated with collagen degradation Arthritis Rheum 43(10): 2202–2210

    Article  PubMed  CAS  Google Scholar 

  14. Hollander AP, Pidoux I, Reiner A, Rorabeck C, Bourne R, Poole AR (1995) damage to type II collagen in ageing and osteoarthritis: starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration. J Clin Invest 96: 2859–2869

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer Basel AG

About this paper

Cite this paper

Ben-Zaken, H., Schneiderman, R., Kaufmann, H., Maroudas, A. (2002). Age-dependent changes in some physico-chemical properties of human articular cartilage. In: Hascall, V.C., Kuettner, K.E. (eds) The Many Faces of Osteoarthritis. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8133-3_24

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-8133-3_24

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9450-0

  • Online ISBN: 978-3-0348-8133-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics