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Type IIA procollagen NH2-propeptide functions as an antagonist of bone morphogenetic proteins

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The Many Faces of Osteoarthritis

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Abstract

Knowledge of how growth factors are regulated in the extracellular matrix is crucial for understanding processes of tissue development and repair. A complex series of processes occurs in the extracellular matrix to control the activity and distribution of bone morphogenetic proteins (BMPs), which are important factors during cartilage and bone development. It is known that tissue regeneration is a recapitulation of processes in embryonic development and morphogenesis. Thus, in the case of cartilage repair during osteoarthritis, we can apply our knowledge of BMP function/regulation during embryogenesis to developing therapeutic strategies that will induce and even prolong natural tissue repair.

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Author information

Authors and Affiliations

  1. Department of Orthopedic Surgery, Washington University School of Medicine at Barnes-Jewish Hospital St Louis, MO, 63110, USA

    Audrey McAlinden, Naoshi Fukui & Linda J. Sandell

Authors
  1. Audrey McAlinden
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  2. Naoshi Fukui
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  3. Linda J. Sandell
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Editor information

Editors and Affiliations

  1. Department of Biomedical Engineering, The Cleveland Clinic Foundation, Orthopaedic Research Center, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Vincent C. Hascall

  2. Department of Biochemistry, Rush Medical College at Rush Presbyterian-St. Luke’s Medical Center, 1653 West Congress Parkway, Chicago, IL, 60612-3864, USA

    Klaus E. Kuettner

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© 2002 Springer Basel AG

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McAlinden, A., Fukui, N., Sandell, L.J. (2002). Type IIA procollagen NH2-propeptide functions as an antagonist of bone morphogenetic proteins. In: Hascall, V.C., Kuettner, K.E. (eds) The Many Faces of Osteoarthritis. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8133-3_1

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  • DOI: https://doi.org/10.1007/978-3-0348-8133-3_1

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9450-0

  • Online ISBN: 978-3-0348-8133-3

  • eBook Packages: Springer Book Archive

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